Change in high-sensitive cardiac troponin T on hypertensive treatment

Satoshi Hoshide, Motoki Fukutomi, Kazuo Eguchi, Tomonori Watanabe, Tomoyuki Kabutoya, Kazuomi Kario

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The aim of this study was to compare the differences in the levels of a highly sensitive cardiac troponin T (Hs-cTnT) between Losartan (LOS) plus hydrochlorothiazide (HCTZ) and amlodipine. Seventy-eight hypertensive patients were randomized to receive LOS/HCTZ or amlodipine for 8 weeks. Both treatments decreased clinic and 24-hour blood pressure to the same extent. The Hs-cTnT level was significantly reduced in the amlodipine group (P < .05), but such a reduction was not found in the LOS/HCTZ group in the upper half group of Hs-cTnT level at baseline. Amlodipine had a more beneficial effect than LOS/HCTZ in patients with high Hs-cTnT levels.

Original languageEnglish
Pages (from-to)40-44
Number of pages5
JournalClinical and Experimental Hypertension
Issue number1
StatePublished - 2013
Externally publishedYes


  • A highly sensitive assay for cardiac troponin T
  • Angiotensin II type I receptor blocker
  • Calcium channel blocker
  • Hydrochlorothiazide
  • Hypertension


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