Change in high-sensitive cardiac troponin T on hypertensive treatment

Satoshi Hoshide; Motoki Fukutomi; Kazuo Eguchi; Tomonori Watanabe; Tomoyuki Kabutoya; Kazuomi Kario

doi:10.3109/10641963.2012.689044

Change in high-sensitive cardiac troponin T on hypertensive treatment

Satoshi Hoshide, Motoki Fukutomi, Kazuo Eguchi, Tomonori Watanabe, Tomoyuki Kabutoya, Kazuomi Kario

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The aim of this study was to compare the differences in the levels of a highly sensitive cardiac troponin T (Hs-cTnT) between Losartan (LOS) plus hydrochlorothiazide (HCTZ) and amlodipine. Seventy-eight hypertensive patients were randomized to receive LOS/HCTZ or amlodipine for 8 weeks. Both treatments decreased clinic and 24-hour blood pressure to the same extent. The Hs-cTnT level was significantly reduced in the amlodipine group (P < .05), but such a reduction was not found in the LOS/HCTZ group in the upper half group of Hs-cTnT level at baseline. Amlodipine had a more beneficial effect than LOS/HCTZ in patients with high Hs-cTnT levels.

Original language	English
Pages (from-to)	40-44
Number of pages	5
Journal	Clinical and Experimental Hypertension
Volume	35
Issue number	1
DOIs	https://doi.org/10.3109/10641963.2012.689044
State	Published - 2013
Externally published	Yes

Keywords

A highly sensitive assay for cardiac troponin T
Angiotensin II type I receptor blocker
Calcium channel blocker
Hydrochlorothiazide
Hypertension

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10.3109/10641963.2012.689044

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title = "Change in high-sensitive cardiac troponin T on hypertensive treatment",

abstract = "The aim of this study was to compare the differences in the levels of a highly sensitive cardiac troponin T (Hs-cTnT) between Losartan (LOS) plus hydrochlorothiazide (HCTZ) and amlodipine. Seventy-eight hypertensive patients were randomized to receive LOS/HCTZ or amlodipine for 8 weeks. Both treatments decreased clinic and 24-hour blood pressure to the same extent. The Hs-cTnT level was significantly reduced in the amlodipine group (P < .05), but such a reduction was not found in the LOS/HCTZ group in the upper half group of Hs-cTnT level at baseline. Amlodipine had a more beneficial effect than LOS/HCTZ in patients with high Hs-cTnT levels.",

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AU - Hoshide, Satoshi

AU - Fukutomi, Motoki

AU - Eguchi, Kazuo

AU - Watanabe, Tomonori

AU - Kabutoya, Tomoyuki

AU - Kario, Kazuomi

PY - 2013

Y1 - 2013

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AB - The aim of this study was to compare the differences in the levels of a highly sensitive cardiac troponin T (Hs-cTnT) between Losartan (LOS) plus hydrochlorothiazide (HCTZ) and amlodipine. Seventy-eight hypertensive patients were randomized to receive LOS/HCTZ or amlodipine for 8 weeks. Both treatments decreased clinic and 24-hour blood pressure to the same extent. The Hs-cTnT level was significantly reduced in the amlodipine group (P < .05), but such a reduction was not found in the LOS/HCTZ group in the upper half group of Hs-cTnT level at baseline. Amlodipine had a more beneficial effect than LOS/HCTZ in patients with high Hs-cTnT levels.

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Change in high-sensitive cardiac troponin T on hypertensive treatment

Abstract

Keywords

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