Change in chromatin organization of the 3′-flanking region of the rat apoprotein E gene in neonatal rats after an increase in transcriptional activity

Edward A. Fisher

Research output: Contribution to journalArticlepeer-review

Abstract

To investigate if a change in chromatin organization is associated with the increased transcriptional activity of the apoprotein E (apo E) gene, a study was done in hepatic nuclei isolated after birth to identify areas in or flanking the rat apo E gene with increased sensitivity to DNase 1. An area of preferential digestion in the 3′-flanking region of the apo E gene was identified in liver nuclei from 3-day-old pups but not in nuclei from fetal livers collected at day 20 of gestation. This hypersensitive area may contain information important for the regulated expression of the rat apo E gene.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalAtherosclerosis
Volume76
Issue number1
DOIs
StatePublished - Mar 1989
Externally publishedYes

Keywords

  • Apoprotein E gene
  • Chromatin organization
  • Rat liver development

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