Challenges in Accurate Diagnosis of HCC in FALD: A Case Series

Monica Feeley; Kali Hopkins; Lauren T. Grinspan; Thomas Schiano; Barry Love; Alice Chan; Sara Lewis; Ali N. Zaidi

doi:10.1007/s00246-023-03207-9

Challenges in Accurate Diagnosis of HCC in FALD: A Case Series

Monica Feeley, Kali Hopkins, Lauren T. Grinspan, Thomas Schiano, Barry Love, Alice Chan, Sara Lewis, Ali N. Zaidi

Research output: Contribution to journal › Review article › peer-review

Abstract

Patients with single ventricle cardiac disease palliated with Fontan procedures inevitably develop Fontan-Associated Liver Disease (FALD), which poses a significant risk for hepatocellular carcinoma (HCC). Standard imaging criteria for the diagnosis of cirrhosis are not reliable due to parenchymal heterogeneity of FALD. We present 6 cases to demonstrate our center’s experience and the challenges in diagnosing HCC within this patient population.

Original language	English
Pages (from-to)	1447-1453
Number of pages	7
Journal	Pediatric Cardiology
Volume	44
Issue number	7
DOIs	https://doi.org/10.1007/s00246-023-03207-9
State	Published - Oct 2023

Keywords

Fontan
Fontan associated liver disease
Hepatocellular carcinoma
Single ventricle

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10.1007/s00246-023-03207-9

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title = "Challenges in Accurate Diagnosis of HCC in FALD: A Case Series",

abstract = "Patients with single ventricle cardiac disease palliated with Fontan procedures inevitably develop Fontan-Associated Liver Disease (FALD), which poses a significant risk for hepatocellular carcinoma (HCC). Standard imaging criteria for the diagnosis of cirrhosis are not reliable due to parenchymal heterogeneity of FALD. We present 6 cases to demonstrate our center{\textquoteright}s experience and the challenges in diagnosing HCC within this patient population.",

keywords = "Fontan, Fontan associated liver disease, Hepatocellular carcinoma, Single ventricle",

author = "Monica Feeley and Kali Hopkins and Grinspan, {Lauren T.} and Thomas Schiano and Barry Love and Alice Chan and Sara Lewis and Zaidi, {Ali N.}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

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T1 - Challenges in Accurate Diagnosis of HCC in FALD

T2 - A Case Series

AU - Feeley, Monica

AU - Hopkins, Kali

AU - Grinspan, Lauren T.

AU - Schiano, Thomas

AU - Love, Barry

AU - Chan, Alice

AU - Lewis, Sara

AU - Zaidi, Ali N.

PY - 2023/10

Y1 - 2023/10

N2 - Patients with single ventricle cardiac disease palliated with Fontan procedures inevitably develop Fontan-Associated Liver Disease (FALD), which poses a significant risk for hepatocellular carcinoma (HCC). Standard imaging criteria for the diagnosis of cirrhosis are not reliable due to parenchymal heterogeneity of FALD. We present 6 cases to demonstrate our center’s experience and the challenges in diagnosing HCC within this patient population.

AB - Patients with single ventricle cardiac disease palliated with Fontan procedures inevitably develop Fontan-Associated Liver Disease (FALD), which poses a significant risk for hepatocellular carcinoma (HCC). Standard imaging criteria for the diagnosis of cirrhosis are not reliable due to parenchymal heterogeneity of FALD. We present 6 cases to demonstrate our center’s experience and the challenges in diagnosing HCC within this patient population.

KW - Fontan

KW - Fontan associated liver disease

KW - Hepatocellular carcinoma

KW - Single ventricle

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U2 - 10.1007/s00246-023-03207-9

DO - 10.1007/s00246-023-03207-9

M3 - Review article

AN - SCOPUS:85161941284

SN - 0172-0643

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SP - 1447

EP - 1453

JO - Pediatric Cardiology

JF - Pediatric Cardiology

IS - 7

ER -

Challenges in Accurate Diagnosis of HCC in FALD: A Case Series

Abstract

Keywords

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