Challenges and Opportunities in dMRI Data Harmonization

Alyssa H. Zhu, Daniel C. Moyer, Talia M. Nir, Paul M. Thompson, Neda Jahanshad

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

15 Scopus citations

Abstract

Advances in diffusion MRI (dMRI) have led to discoveries of factors that affect brain microstructure and connectivity in health and disease. The small size of many neuroimaging studies led to concerns about poor reproducibility of research findings, and calls for the comparison and pooling of multi-cohort datasets to establish the consistency of reported effects. Across studies diffusion MRI protocols vary in spatial, angular and q-space resolution, b-value, as well as hardware used—all of which affect measured diffusion parameters. Efforts to compare and pool dMRI measures use meta- or mega- analytical techniques to compensate for these sources of variance. Meta-analytical methods gauge the consistency of effects, and mega-analytical methods involve mathematical or statistical transformations of the data. Here, we review some recent advances that allowed the diffusion community to create large scale population studies with greater rigor and generalizability than was previously attainable by individual studies.

Original languageEnglish
Title of host publicationMathematics and Visualization
EditorsElisenda Bonet-Carne, Francesco Grussu, Lipeng Ning, Farshid Sepehrband, Chantal M.W. Tax
PublisherSpringer Heidelberg
Pages157-172
Number of pages16
ISBN (Print)9783030058302
DOIs
StatePublished - 2019
Externally publishedYes
EventInternational Workshop on Computational Diffusion MRI, CDMRI 2018 held with International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018 - Granada, Spain
Duration: 20 Sep 201820 Sep 2018

Publication series

NameMathematics and Visualization
ISSN (Print)1612-3786
ISSN (Electronic)2197-666X

Conference

ConferenceInternational Workshop on Computational Diffusion MRI, CDMRI 2018 held with International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018
Country/TerritorySpain
CityGranada
Period20/09/1820/09/18

Keywords

  • DTI
  • DWI
  • Harmonization
  • Multi-site
  • diffusion MRI

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