Abstract
Array comparative genomic hybridization (aCGH) is an emerging technology for measuring genome-wide DNA copy number. aCGH has been demonstrated as an effective tool in gene discovery and disease classification in cancer and other genetic disorders. This review describes recently employed analysis techniques for genomic copy number profiling using aCGH with a particular focus on how established gene expression array analysis techniques can be adapted for analysis of aCGH data. We intend this review to propose a framework to guide ongoing and future research in aCGH data analysis.
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics |
| Subtitle of host publication | Dunn/Genomics |
| Publisher | wiley |
| Pages | 1-8 |
| Number of pages | 8 |
| ISBN (Electronic) | 9780470011539 |
| ISBN (Print) | 9780470849743 |
| DOIs | |
| State | Published - 1 Jan 2006 |
| Externally published | Yes |
Keywords
- CGH
- cancer
- comparative genomic hybridization
- data analysis
- microarray