Cessation of neoangiogenesis in Alzheimer's disease follows amyloid-beta immunization

Kaan E. Biron, Dara L. Dickstein, Rayshad Gopaul, Franz Fenninger, Wilfred A. Jefferies

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Pathogenic neoangiogenesis in Alzheimer's disease (AD) is due to amyloid-beta (Aβ) and results in blood-brain barrier (BBB) leakiness in AD. It likely occurs as a compensatory response to impaired cerebral blood flow and provides a strong link between brain vascularity and AD. Aβ immunotherapy is an experimental treatment for AD; however, unexpected negative vascular side effects seen in early human clinical trials demonstrate that our knowledge of Aβ and AD pathogenesis is incomplete. We demonstrate that immunization with Aβ peptides neutralizes the amyloid trigger leading to neoangiogenesis and reverses hypervascularity in Tg2576 AD mice. This process resolves plaque burden suggesting that neoangiogenesis is a key mechanism underlying plaque formation. A meta-analysis demonstrated that hypervascular reversion in vaccinated Alzheimer's patients. This appears to be the first example of vascular reversion following any therapeutic intervention and supports the conclusion that modulation of neoangiogenesis may repair damage in the AD brain.

Original languageEnglish
Article number1354
JournalScientific Reports
Volume3
DOIs
StatePublished - 2013

Fingerprint

Dive into the research topics of 'Cessation of neoangiogenesis in Alzheimer's disease follows amyloid-beta immunization'. Together they form a unique fingerprint.

Cite this