Cessation of asthma medication in early pregnancy

Rachel Enriquez, Pingsheng Wu, Marie R. Griffin, Tebeb Gebretsadik, Ayumi Shintani, Ed Mitchel, Kecia N. Carroll, Tina V. Hartert

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


Objective: The objective of the study was to determine whether women alter their use of asthma medications during pregnancy. Study design: Weekly asthma medication use was determined from prescription claims data in a cohort of 112,171 pregnant women aged 15 to 44 years who were continuously enrolled in the Tennessee Medicaid program prior to their singleton pregnancy and who delivered a singleton birth during 1995 to 2001. Change in asthma medication use was evaluated using generalized estimating equation analyses. Results: Women with asthma significantly (P ≤ 0.0005) decreased their asthma medication use from 5 to 13 weeks of pregnancy. During the first trimester, there was a 23% decline in inhaled corticosteroid prescriptions, a 13% decline in short-acting beta-agonist prescriptions, and a 54% decline in rescue corticosteroid prescriptions. Conclusions: Utilization of all categories of asthma medications decreased in early pregnancy, with the largest declines occurring for inhaled and rescue corticosteroids.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
StatePublished - Jul 2006
Externally publishedYes


  • Asthma
  • Drug utilization
  • Guidelines
  • Medicaid database
  • Pregnancy


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