Cervical lymphadenopathy from PRP treatment with microneedling therapy

Background: Platelet-rich plasma is highly enriched plasma that contains a large concentration of platelets that secrete various growth factors and is used in a wide variety of surgical and cosmetic procedures, including hair regrowth and skin rejuvenation. Methods: Microneedling therapy is being combined with platelet-rich plasma to potentiate patient's cosmetic effects. While microneedling therapy and platelet-rich plasma therapy have been around for years and are growing in popularity internationally, there are limited data regarding complications when they are used in conjunction. Results: We present a case in which a patient presented with acute, painful lymphadenopathy shortly after undergoing the combination treatment of a microneedling pen with platelet-rich plasma therapy. Conclusion: Individuals should know of the potential adverse effect of microneedling pen therapy used in conjunction with platelet-rich plasma therapy, and it should be included in patient consent forms and doctor–patient education.