Cerebrovascular perfusion among older adults is moderated by strength training and gender

Xiaomeng Xu, Beth A. Jerskey, Denise M. Cote, Edward G. Walsh, Jason J. Hassenstab, Maura E. Ladino, Uraina S. Clark, Donald R. Labbe, John J. Gunstad, Athena Poppas, Ronald A. Cohen, Richard D. Hoge, Lawrence H. Sweet

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Cerebral perfusion is important in older adults as it is linked to cognitive declines. Physical activity can improve blood flow in the body but little is known about the relationship between physical activity and cerebral perfusion in older adults. In particular, no study has investigated the relation between strength training and cerebral perfusion. We examined whether different types of physical activity (assessed with the Rapid Assessment of Physical Activity questionnaire) were associated with MRI cerebrovascular perfusion in 59 older adults. There was a significant interaction between gender and strength training, such that women who engaged in strength training (weight lifting or calisthenics) at least once per week exhibited significantly greater cerebrovascular perfusion than women who did not. This interaction remained significant after controlling for other physical activity, demographics, and health variables. These findings suggest that regular strength training can be beneficial for cerebrovascular health in women.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalNeuroscience Letters
StatePublished - 7 Feb 2014


  • ASL
  • Cerebral perfusion
  • Physical activity
  • Sex
  • Strength training


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