Cerebrospinal fluid paraproteins in multiple myeloma

Arthur H. Weiss, Eugene Smith, Nicholas Christoff, Shaul Kochwa

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Serum and cerebrospinal fluid specimens from 28 patients with multiple myeloma and 1 patient with Waldenström's macroglobulinemia were examined by disc electrophoresis on acrylamide gel, immunoelectrophoresis, and, in some cases ultracentrifugation. Eight of the myeloma patients had increased cerebrospinal fluid total protein concentration. Six of these elevations could be explained by neurological disease. The presence of paraproteins alone did not appear to cause elevation of the total CSF protein. There was no relationship between total serum and spinal-fluid protein concentrations. All 7S gamma-G myeloma patients revealed the presence of the paraprotein in the cerebrospinal fluid. One unusual myeloma patient with a 14S aggregate protein in the serum and the patient with Waldenström's macroglobulinemia did not show paraproteins in the spinal fluid. In 5 cases of gamma-A myeloma the 7S paraprotein and its low molecular weight complexes were identified in the spinal fluid while the larger aggregates could not be detected in these specimens. These findings suggest that in the presence of an intact central nervous system only proteins of certain molecular size penetrate into the Cerebrospinal fluid.

Original languageEnglish
Pages (from-to)280-293
Number of pages14
JournalTranslational Research
Issue number2
StatePublished - Aug 1965


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