Cerebrospinal fluid d-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients

Sabine A. Fuchs; Martina M.J. De Barse; Floor E. Scheepers; Wiepke Cahn; Lambertus Dorland; Monique G. de Sain-van der Velden; Leo W.J. Klomp; Ruud Berger; René S. Kahn; Tom J. de Koning

doi:10.1016/j.euroneuro.2007.12.002

Cerebrospinal fluid d-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients

Sabine A. Fuchs, Martina M.J. De Barse, Floor E. Scheepers, Wiepke Cahn, Lambertus Dorland, Monique G. de Sain-van der Velden, Leo W.J. Klomp, Ruud Berger, René S. Kahn, Tom J. de Koning

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

N-Methyl d-aspartate (NMDA)-receptor hypofunction has been implicated in the pathophysiology of schizophrenia and d-serine and glycine add-on therapy to antipsychotics has shown beneficial effects in schizophrenic patients. Nevertheless, previous studies have not shown consistently altered d-serine concentrations in cerebrospinal fluid (CSF) of schizophrenic patients. To confirm and extend these results, CSF concentrations of both endogenous NMDA-receptor co-agonists d-serine and glycine and their common precursor l-serine were analyzed simultaneously in 17 healthy controls and 19 schizophrenic patients before and 6 weeks after daily olanzapine (10 mg) treatment. CSF d-serine, l-serine and glycine concentrations and their relative ratios were similar between schizophrenic patients and controls and no differences were observed before and after olanzapine therapy. Thus, the NMDA-receptor hypofunction hypothesis in schizophrenia is not explained by olanzapine therapy-dependent absolute or relative decreases in CSF d-serine and glycine concentrations in this series of male patients, thereby not providing convenient markers for the disorder.

Original language	English
Pages (from-to)	333-338
Number of pages	6
Journal	European Neuropsychopharmacology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.euroneuro.2007.12.002
State	Published - May 2008
Externally published	Yes

Keywords

Cerebrospinal fluid
Glycine;
NMDA-receptor;
Olanzapine;
Schizophrenia;
d-Serine;

Access to Document

10.1016/j.euroneuro.2007.12.002

Cite this

Fuchs, S. A., De Barse, M. M. J., Scheepers, F. E., Cahn, W., Dorland, L., de Sain-van der Velden, M. G., Klomp, L. W. J., Berger, R., Kahn, R. S., & de Koning, T. J. (2008). Cerebrospinal fluid d-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients. European Neuropsychopharmacology, 18(5), 333-338. https://doi.org/10.1016/j.euroneuro.2007.12.002

@article{73d218061c3c40bfad4acb45c773a54f,

title = "Cerebrospinal fluid d-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients",

abstract = "N-Methyl d-aspartate (NMDA)-receptor hypofunction has been implicated in the pathophysiology of schizophrenia and d-serine and glycine add-on therapy to antipsychotics has shown beneficial effects in schizophrenic patients. Nevertheless, previous studies have not shown consistently altered d-serine concentrations in cerebrospinal fluid (CSF) of schizophrenic patients. To confirm and extend these results, CSF concentrations of both endogenous NMDA-receptor co-agonists d-serine and glycine and their common precursor l-serine were analyzed simultaneously in 17 healthy controls and 19 schizophrenic patients before and 6 weeks after daily olanzapine (10 mg) treatment. CSF d-serine, l-serine and glycine concentrations and their relative ratios were similar between schizophrenic patients and controls and no differences were observed before and after olanzapine therapy. Thus, the NMDA-receptor hypofunction hypothesis in schizophrenia is not explained by olanzapine therapy-dependent absolute or relative decreases in CSF d-serine and glycine concentrations in this series of male patients, thereby not providing convenient markers for the disorder.",

keywords = "Cerebrospinal fluid, Glycine;, NMDA-receptor;, Olanzapine;, Schizophrenia;, d-Serine;",

author = "Fuchs, \{Sabine A.\} and \{De Barse\}, \{Martina M.J.\} and Scheepers, \{Floor E.\} and Wiepke Cahn and Lambertus Dorland and \{de Sain-van der Velden\}, \{Monique G.\} and Klomp, \{Leo W.J.\} and Ruud Berger and Kahn, \{Ren{\'e} S.\} and \{de Koning\}, \{Tom J.\}",

note = "Funding Information: Funding for this study was provided by The Netherlands Organization for Health Research and Development (to S.A.F: 920-03-345); the Netherlands Organization for Health Research and Development had no further role in study design, in the collection, analysis and interpretation of the data, in the writing of the report and in the decision to submit the paper for publication. Funding Information: We gratefully acknowledge financial support from The Netherlands Organization for Health Research and Development (to S.A.F.: 920-03-345). We are indebted to the patients who participated in this study; to the laboratory of microbiology of the University Medical Center Utrecht for their collaboration in cerebrospinal fluid collection; to Dr. D. de Vries (University Medical Center Utrecht, the Netherlands) for the statistical analysis and to Dr. CPMC Peeters (VU University Medical Center, Amsterdam, The Netherlands) for the helpful discussions.",

year = "2008",

month = may,

doi = "10.1016/j.euroneuro.2007.12.002",

language = "English",

volume = "18",

pages = "333--338",

journal = "European Neuropsychopharmacology",

issn = "0924-977X",

publisher = "Elsevier B.V.",

number = "5",

}

Fuchs, SA, De Barse, MMJ, Scheepers, FE, Cahn, W, Dorland, L, de Sain-van der Velden, MG, Klomp, LWJ, Berger, R, Kahn, RS & de Koning, TJ 2008, 'Cerebrospinal fluid d-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients', European Neuropsychopharmacology, vol. 18, no. 5, pp. 333-338. https://doi.org/10.1016/j.euroneuro.2007.12.002

TY - JOUR

T1 - Cerebrospinal fluid d-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients

AU - Fuchs, Sabine A.

AU - De Barse, Martina M.J.

AU - Scheepers, Floor E.

AU - Cahn, Wiepke

AU - Dorland, Lambertus

AU - de Sain-van der Velden, Monique G.

AU - Klomp, Leo W.J.

AU - Berger, Ruud

AU - Kahn, René S.

AU - de Koning, Tom J.

N1 - Funding Information: Funding for this study was provided by The Netherlands Organization for Health Research and Development (to S.A.F: 920-03-345); the Netherlands Organization for Health Research and Development had no further role in study design, in the collection, analysis and interpretation of the data, in the writing of the report and in the decision to submit the paper for publication. Funding Information: We gratefully acknowledge financial support from The Netherlands Organization for Health Research and Development (to S.A.F.: 920-03-345). We are indebted to the patients who participated in this study; to the laboratory of microbiology of the University Medical Center Utrecht for their collaboration in cerebrospinal fluid collection; to Dr. D. de Vries (University Medical Center Utrecht, the Netherlands) for the statistical analysis and to Dr. CPMC Peeters (VU University Medical Center, Amsterdam, The Netherlands) for the helpful discussions.

PY - 2008/5

Y1 - 2008/5

N2 - N-Methyl d-aspartate (NMDA)-receptor hypofunction has been implicated in the pathophysiology of schizophrenia and d-serine and glycine add-on therapy to antipsychotics has shown beneficial effects in schizophrenic patients. Nevertheless, previous studies have not shown consistently altered d-serine concentrations in cerebrospinal fluid (CSF) of schizophrenic patients. To confirm and extend these results, CSF concentrations of both endogenous NMDA-receptor co-agonists d-serine and glycine and their common precursor l-serine were analyzed simultaneously in 17 healthy controls and 19 schizophrenic patients before and 6 weeks after daily olanzapine (10 mg) treatment. CSF d-serine, l-serine and glycine concentrations and their relative ratios were similar between schizophrenic patients and controls and no differences were observed before and after olanzapine therapy. Thus, the NMDA-receptor hypofunction hypothesis in schizophrenia is not explained by olanzapine therapy-dependent absolute or relative decreases in CSF d-serine and glycine concentrations in this series of male patients, thereby not providing convenient markers for the disorder.

AB - N-Methyl d-aspartate (NMDA)-receptor hypofunction has been implicated in the pathophysiology of schizophrenia and d-serine and glycine add-on therapy to antipsychotics has shown beneficial effects in schizophrenic patients. Nevertheless, previous studies have not shown consistently altered d-serine concentrations in cerebrospinal fluid (CSF) of schizophrenic patients. To confirm and extend these results, CSF concentrations of both endogenous NMDA-receptor co-agonists d-serine and glycine and their common precursor l-serine were analyzed simultaneously in 17 healthy controls and 19 schizophrenic patients before and 6 weeks after daily olanzapine (10 mg) treatment. CSF d-serine, l-serine and glycine concentrations and their relative ratios were similar between schizophrenic patients and controls and no differences were observed before and after olanzapine therapy. Thus, the NMDA-receptor hypofunction hypothesis in schizophrenia is not explained by olanzapine therapy-dependent absolute or relative decreases in CSF d-serine and glycine concentrations in this series of male patients, thereby not providing convenient markers for the disorder.

KW - Cerebrospinal fluid

KW - Glycine;

KW - NMDA-receptor;

KW - Olanzapine;

KW - Schizophrenia;

KW - d-Serine;

UR - https://www.scopus.com/pages/publications/40849087780

U2 - 10.1016/j.euroneuro.2007.12.002

DO - 10.1016/j.euroneuro.2007.12.002

M3 - Article

C2 - 18261886

AN - SCOPUS:40849087780

SN - 0924-977X

VL - 18

SP - 333

EP - 338

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 5

ER -

Cerebrospinal fluid d-serine and glycine concentrations are unaltered and unaffected by olanzapine therapy in male schizophrenic patients

Abstract

Keywords

Access to Document

Fingerprint

Cite this