Charles Mackel, Yakov Gologorsky, Ron Alterman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Over the last four decades, the field of deep cerebral neuromodulation has developed rapidly. Chronic electrical deep brain stimulation has supplanted neuroablation as the primary neuromodulatory technique. Deep brain stimulation is currently the standard treatment for medically refractory essential tremor, Parkinson's disease, and primary dystonia. The treatments of obsessive-compulsive disorder and epilepsy with DBS are also approved in the United States and European Union. This chapter provides a broad overview of the deep cerebral targets currently employed or under investigation for neuromodulatory therapy. This chapter also reviews the additional diseases for which DBS neuromodulation has been proposed as a treatment modality, which includes assorted pathologies of pain, psychiatry, and cognition that span from cluster headaches to major depression to Alzheimer's. The scientific/physiologic rationale for modulating specific deep cerebral targets is discussed, and the key clinical research findings of Phase I–III trials and observational studies are highlighted.

Original languageEnglish
Title of host publicationEssential Neuromodulation
Number of pages39
ISBN (Electronic)9780128170007
StatePublished - 1 Jan 2022


  • Basal ganglia
  • Deep cerebral
  • Dystonia
  • Epilepsy
  • Obsessive-compulsive
  • Pain
  • Parkinson's
  • Psychiatric
  • Thalamus
  • Tremor


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