TY - JOUR
T1 - Cerebral microbleeds and cognitive functioning in the PROSPER study
AU - Van Es, A. C.G.M.
AU - Van Der Grond, J.
AU - De Craen, A. J.M.
AU - Westendorp, R. G.J.
AU - Bollen, E. L.E.M.
AU - Blauw, G. J.
AU - Greenberg, S. M.
AU - Van Buchem, M. A.
N1 - Funding Information:
A.C.G.M. van Es, Dr. van der Grond, and Dr. J.M. de Craen report no disclosures. Dr. Westendorp serves on the editorial boards of Experimental Gerontology, Ageing Research Reviews, The Netherlands Journal of Internal Medicine, and Age and Ageing; and receives research support from National Genomics Initiative, EC/FP6, IOP, and NWO; and is executive director of Leyden Academy on Vitality and Ageing. Dr. Bollen and Dr. Blauw report no disclosures. Dr. Greenberg serves on a data safety monitoring board for the NIH/NINDS; has received speaker honoraria from Esteve, Medtronics, Inc., and Pfizer Inc; serves on the editorial boards of Neurology®, Stroke, Cerebrovascular Disease, and the Journal of Alzheimer's Disease and Other Dementias; has served as a consultant for Roche, Janssen Alzheimer Immunotherapy, and Bristol-Myers Squibb; and has received/receives research support from the NIH and the Alzheimer's Association. Dr. van Buchem reports no disclosures.
PY - 2011/10/11
Y1 - 2011/10/11
N2 - Objectives: Cerebral microbleeds (MBs) are an important indicator of cerebral small-vessel disease, and their prevalence increases with increasing age. Little is known about the functional consequences of MBs in the aging population. In this study we investigated whether the presence and location of MBs are associated with cognition in the PROSPER study. Methods: For 439 subjects the number and location (cortico-subcortical, deep white matter, basal ganglia, and infratentorial) of the MBs was recorded. Difference in cognitive performance between subjects with and without MBs was calculated by entering the variables sex, age, white matter hyperintensity volume, infarction, and MBs in a linear mixed model. Differences in cognition between subjects with and without one or more MBs at different anatomic locations were assessed using the same model. Results: We found that after correction for sex, age, white matter hyperintensity volume, and infarction, subjects with infratentorial MBs had a significantly lower score on the Immediate Picture-Word Learning test, Delayed Picture-Word Learning, and Instrumental Activities of Daily Living. Conclusions: Our data demonstrate that in elderly individuals at increased vascular risk, infratentorial MBs are associated with loss in cognitive functioning.
AB - Objectives: Cerebral microbleeds (MBs) are an important indicator of cerebral small-vessel disease, and their prevalence increases with increasing age. Little is known about the functional consequences of MBs in the aging population. In this study we investigated whether the presence and location of MBs are associated with cognition in the PROSPER study. Methods: For 439 subjects the number and location (cortico-subcortical, deep white matter, basal ganglia, and infratentorial) of the MBs was recorded. Difference in cognitive performance between subjects with and without MBs was calculated by entering the variables sex, age, white matter hyperintensity volume, infarction, and MBs in a linear mixed model. Differences in cognition between subjects with and without one or more MBs at different anatomic locations were assessed using the same model. Results: We found that after correction for sex, age, white matter hyperintensity volume, and infarction, subjects with infratentorial MBs had a significantly lower score on the Immediate Picture-Word Learning test, Delayed Picture-Word Learning, and Instrumental Activities of Daily Living. Conclusions: Our data demonstrate that in elderly individuals at increased vascular risk, infratentorial MBs are associated with loss in cognitive functioning.
UR - http://www.scopus.com/inward/record.url?scp=82955236203&partnerID=8YFLogxK
U2 - 10.1212/WNL.0b013e318232ab1d
DO - 10.1212/WNL.0b013e318232ab1d
M3 - Article
AN - SCOPUS:82955236203
SN - 0028-3878
VL - 77
SP - 1446
EP - 1452
JO - Neurology
JF - Neurology
IS - 15
ER -