TY - JOUR
T1 - Cerebral metabolism and mood in remitted opiate dependence
AU - Galynker, Igor I.
AU - Eisenberg, Daniel
AU - Matochik, John A.
AU - Gertmenian-King, Enid
AU - Cohen, Lisa
AU - Kimes, Alane S.
AU - Contoreggi, Carlo
AU - Kurian, Varughese
AU - Ernst, Monique
AU - Rosenthal, Richard N.
AU - Prosser, James
AU - London, Edythe D.
N1 - Funding Information:
This study was supported in part by RO1 DA 12273 (to Dr. Galynker), the NIDA Intramural Research Program, and the Counterdrug Technology Center, Office of National Drug Control Policy.
PY - 2007/10/8
Y1 - 2007/10/8
N2 - Background: Opiate-dependent individuals are prone to dysphoria that may contribute to treatment failure. Methadone-maintenance therapy (MMT) may mitigate this vulnerability, but controversy surrounds its long-term use. Little is known about the neurobiology of mood dysregulation in individuals receiving or removed from MMT. Methods: Fifteen opiate-abstinent and 12 methadone-maintained, opiate-dependent subjects, who lacked other Axis I pathology, and 13 control subjects were compared on the Cornell Dysthymia Rating Scale (CDRS) and regional cerebral glucose metabolism (rCMRglc) using [18F]fluorodeoxyglucose positron emission tomography. Results: CDRS scores showed no group differences. Opiate-abstinent subjects had lower rCMRglc than control subjects in the bilateral perigenual anterior cingulate cortex (ACC), left mid-cingulate cortex, left insula and right superior frontal cortex. Methadone-maintained subjects exhibited lower rCMRglc than control subjects in the left insula and thalamus. In opiate-abstinent subjects, rCMRglc in the left perigenual ACC and mid-cingulate cortex correlated positively with CDRS scores. Conclusions: In remitted heroin dependence, opiate-abstinence is associated with more widespread patterns of abnormal cortical activity than MMT. Aberrant mood processing in the left perigenual ACC and mid-cingulate cortex, seen in opiate-abstinent individuals, is absent in those receiving MMT, suggesting that methadone may improve mood regulation in this population.
AB - Background: Opiate-dependent individuals are prone to dysphoria that may contribute to treatment failure. Methadone-maintenance therapy (MMT) may mitigate this vulnerability, but controversy surrounds its long-term use. Little is known about the neurobiology of mood dysregulation in individuals receiving or removed from MMT. Methods: Fifteen opiate-abstinent and 12 methadone-maintained, opiate-dependent subjects, who lacked other Axis I pathology, and 13 control subjects were compared on the Cornell Dysthymia Rating Scale (CDRS) and regional cerebral glucose metabolism (rCMRglc) using [18F]fluorodeoxyglucose positron emission tomography. Results: CDRS scores showed no group differences. Opiate-abstinent subjects had lower rCMRglc than control subjects in the bilateral perigenual anterior cingulate cortex (ACC), left mid-cingulate cortex, left insula and right superior frontal cortex. Methadone-maintained subjects exhibited lower rCMRglc than control subjects in the left insula and thalamus. In opiate-abstinent subjects, rCMRglc in the left perigenual ACC and mid-cingulate cortex correlated positively with CDRS scores. Conclusions: In remitted heroin dependence, opiate-abstinence is associated with more widespread patterns of abnormal cortical activity than MMT. Aberrant mood processing in the left perigenual ACC and mid-cingulate cortex, seen in opiate-abstinent individuals, is absent in those receiving MMT, suggesting that methadone may improve mood regulation in this population.
KW - Abstinence
KW - Depression
KW - Heroin
KW - Methadone
KW - Mood
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=34548013967&partnerID=8YFLogxK
U2 - 10.1016/j.drugalcdep.2007.03.015
DO - 10.1016/j.drugalcdep.2007.03.015
M3 - Article
C2 - 17521829
AN - SCOPUS:34548013967
SN - 0376-8716
VL - 90
SP - 166
EP - 174
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
IS - 2-3
ER -