Cerebral complications of murine monoclonal CD3 antibody (OKT3): CT and MR findings

Paul M. Parizel, Hans Willem Snoeck, Luc Van Den Hauwe, Katia Boven, Jean Louis Bosmans, Johan W. Van Goethem, Erik A. Van Marck, Patrick Cras, Arthur M. De Schepper, Marc E. De Broe

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26 Scopus citations


Treatment of acute renal allograft rejection with mouse monoclonal antibody (OKT3) is associated with systemic and neurologic side effects. We describe cerebral abnormalities in a 13-year-old boy with steroid-resistant renal allograft rejection. After treatment with OKT3, an acute neurologic syndrome developed, including seizures, lethargy, and decreased mental function. CT and MR imaging revealed confluent cerebral lesions at the corticomedullary junction. Contrast-enhanced MR images showed patchy enhancement, indicating blood-brain barrier dysfunction. The diagnosis of OKT3-induced encephatopathy with cerebral edema and capillary leak syndrome was made. Although CT and MR findings are nonspecific, neuroradiologists should be aware of this condition in transplant patients treated with OKT3.

Original languageEnglish
Pages (from-to)1935-1938
Number of pages4
JournalAmerican Journal of Neuroradiology
Issue number10
StatePublished - Nov 1997
Externally publishedYes


  • Brain, diseases
  • Latrogenic disease or disorder
  • Transplants


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