Centromedian thalamic responsive neurostimulation for Lennox-Gastaut epilepsy and autism

Churl Su Kwon; Alexander J. Schupper; Madeline C. Fields; Lara V. Marcuse; Maite La Vega-Talbott; Fedor Panov; Saadi Ghatan

doi:10.1002/acn3.51173

Centromedian thalamic responsive neurostimulation for Lennox-Gastaut epilepsy and autism

Churl Su Kwon, Alexander J. Schupper, Madeline C. Fields, Lara V. Marcuse, Maite La Vega-Talbott, Fedor Panov, Saadi Ghatan

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug-resistant epilepsy secondary to Lennox-Gastaut Syndrome (LGS) and autism spectrum disorder (ASD) treated with the RNS System. Both patients have experienced 75–99% clinical seizure reductions in >1 year of follow-up. We illustrate that children with diffuse onset, multifocal epilepsy, including frontal and thalamic circuits thought to exist in the generation of LGS seizures, can be treated with responsive neurostimulation safely and effectively, targeting thalamic networks, and avoiding palliative disconnections and resections.

Original language	English
Pages (from-to)	2035-2040
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	7
Issue number	10
DOIs	https://doi.org/10.1002/acn3.51173
State	Published - 1 Oct 2020

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abstract = "The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug-resistant epilepsy secondary to Lennox-Gastaut Syndrome (LGS) and autism spectrum disorder (ASD) treated with the RNS System. Both patients have experienced 75–99% clinical seizure reductions in >1 year of follow-up. We illustrate that children with diffuse onset, multifocal epilepsy, including frontal and thalamic circuits thought to exist in the generation of LGS seizures, can be treated with responsive neurostimulation safely and effectively, targeting thalamic networks, and avoiding palliative disconnections and resections.",

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AU - Marcuse, Lara V.

AU - La Vega-Talbott, Maite

AU - Panov, Fedor

AU - Ghatan, Saadi

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AB - The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug-resistant epilepsy secondary to Lennox-Gastaut Syndrome (LGS) and autism spectrum disorder (ASD) treated with the RNS System. Both patients have experienced 75–99% clinical seizure reductions in >1 year of follow-up. We illustrate that children with diffuse onset, multifocal epilepsy, including frontal and thalamic circuits thought to exist in the generation of LGS seizures, can be treated with responsive neurostimulation safely and effectively, targeting thalamic networks, and avoiding palliative disconnections and resections.

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Centromedian thalamic responsive neurostimulation for Lennox-Gastaut epilepsy and autism

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