Central role of podocytes in mediating cellular cross talk in glomerular health and disease

Nehaben A. Gujarati, Andrew K. Chow, Sandeep K. Mallipattu

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Podocytes are highly specialized epithelial cells that surround the capillaries of the glomeruli in the kidney. Together with the glomerular endothelial cells, these postmitotic cells are responsible for regulating filtrate from the circulating blood with their organized network of interdigitating foot processes that wrap around the glomerular basement membrane. Although podocyte injury and subsequent loss is the hallmark of many glomerular diseases, recent evidence suggests that the cell-cell communication between podocytes and other glomerular and nonglomerular cells is critical for the development and progression of kidney disease. In this review, we highlight these key cellular pathways of communication and how they might be a potential target for therapy in glomerular disease. We also postulate that podocytes might serve as a central hub for communication in the kidney under basal conditions and in response to cellular stress, which may have implications for the development and progression of glomerular diseases.

Original languageEnglish
Pages (from-to)F313-F325
JournalAmerican Journal of Physiology - Renal Physiology
Volume326
Issue number3
DOIs
StatePublished - Mar 2024
Externally publishedYes

Keywords

  • cellular cross talk
  • glomerular diseases
  • kidney disease
  • podocytes

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