Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Alberto Paniz-Mondolfi, Clare Bryce, Zachary Grimes, Ronald E. Gordon, Jason Reidy, John Lednicky, Emilia Mia Sordillo, Mary Fowkes

Research output: Contribution to journalComment/debate

733 Scopus citations

Abstract

Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS-CoV-2.

Original languageEnglish
Pages (from-to)699-702
Number of pages4
JournalJournal of Medical Virology
Volume92
Issue number7
DOIs
StatePublished - 1 Jul 2020

Keywords

  • CNS infection
  • SARS-CoV-2
  • endothelium
  • neuroinvasion
  • neurotropism

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