Central nervous system (CNS) enterovirus infections: A single center retrospective study on clinical features, diagnostic studies, and outcome

Sarah D. Torres, Dan Tong Jia, Emily M. Schorr, Brian L. Park, Alexandra Boubour, Amelia Boehme, Jyoti V. Ankam, Jacqueline S. Gofshteyn, Charles Tyshkov, Daniel A. Green, Wendy Vargas, Jason Zucker, Anusha K. Yeshokumar, Kiran T. Thakur

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Enteroviruses (EV) are responsible for a large number of meningoencephalitis cases, especially in children. The objective of this study was to identify modes of diagnosis including the significance of respiratory and cerebrospinal fluid samples, associated clinical characteristics, inpatient management, and outcome of individuals with EV infections of the central nervous system (CNS). Electronic medical records of individuals with enterovirus infections of the CNS who presented to the Columbia University Irving Medical Center and Children’s Hospital of New York between January 1, 2012 and December 31, 2017 were reviewed retrospectively for demographic, epidemiological, and clinical data. The median age overall was 1.7 months (interquartile range 14 years) and most (62.4%) were male. The majority of CNS infections presented as meningitis (95.7%) and occurred in the summer (45.2%) and fall seasons (37.6%). Eighty-five cases (91.4%) demonstrated EV positivity in cerebrospinal fluid, thirty cases (32.3%) exhibited both cerebrospinal fluid and respiratory positivity, and eight cases (8.6%) exhibited respiratory positivity with coinciding neurological findings. Eighty-nine individuals overall (95.7%) received antibiotics and 37 (39.8%) received antiviral treatment. All surviving individuals had favorable Modified Rankin Scores (MRS) within the zero to two ranges upon discharge. Testing respiratory samples in addition to cerebrospinal fluid was found to be an important diagnostic tool in EV-associated cases. While clinical outcomes were favorable for an overwhelming majority of cases, etiological understanding of CNS infections is essential for identifying ongoing and changing epidemiological patterns and aid in improving the diagnosis and treatment.

Original languageEnglish
Pages (from-to)14-22
Number of pages9
JournalJournal of NeuroVirology
Volume26
Issue number1
DOIs
StatePublished - 1 Feb 2020

Keywords

  • Acute flaccid myelitis
  • Central nervous system infections
  • Enterovirus
  • Neurodiagnostics
  • Pediatrics

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