TY - JOUR
T1 - Cellular uptake and photosensitizing properties of anticancer porphyrins in cell membranes and low and high density lipoproteins
AU - Maziere, J. C.
AU - Santus, R.
AU - Morliere, P.
AU - Reyftmann, J. P.
AU - Candide, C.
AU - Mora, L.
AU - Salmon, S.
AU - Maziere, C.
AU - Gatt, S.
AU - Dubertret, L.
N1 - Funding Information:
J. C. Mazi~re gratefully acknowledges La Ligue Nationale Franqaise Contre le Cancer, Comit6 de Paris, for financial support. S. Gatt wishes to thank the Museum National d'Histoire Naturelle for financial support during his stay in Paris.
PY - 1990/6
Y1 - 1990/6
N2 - The mechanisms of the phototoxic effect of anticancer porphyrins used in the photodynamic therapy (PDT) of tumours are not yet completely understood. Irradiation of porphyrins gives rise to singlet oxygen which reacts with key residues of proteins, polyunsaturated fatty acids and cholesterol in membranes, leading to inactivation of various enzymes and transporters. Lipoproteins, mainly low density lipoproteins (LDL), are efficient carriers of anticancer porphyrins in blood and can deliver these photosensitizers to tissues through the apolipoprotein (apo) B/E specific LDL receptor pathway. In this review, we discuss some aspects of anticancer porphyrin transport, cellular uptake and photosensitizing properties in cell membranes and lipoproteins.
AB - The mechanisms of the phototoxic effect of anticancer porphyrins used in the photodynamic therapy (PDT) of tumours are not yet completely understood. Irradiation of porphyrins gives rise to singlet oxygen which reacts with key residues of proteins, polyunsaturated fatty acids and cholesterol in membranes, leading to inactivation of various enzymes and transporters. Lipoproteins, mainly low density lipoproteins (LDL), are efficient carriers of anticancer porphyrins in blood and can deliver these photosensitizers to tissues through the apolipoprotein (apo) B/E specific LDL receptor pathway. In this review, we discuss some aspects of anticancer porphyrin transport, cellular uptake and photosensitizing properties in cell membranes and lipoproteins.
KW - Anticancer porphyrins
KW - high density lipoprotein (HDL).
KW - low density lipoprotein (LDL)
KW - membrane
KW - photosensitization
UR - http://www.scopus.com/inward/record.url?scp=0025440294&partnerID=8YFLogxK
U2 - 10.1016/1011-1344(90)85074-7
DO - 10.1016/1011-1344(90)85074-7
M3 - Article
C2 - 2121939
AN - SCOPUS:0025440294
SN - 1011-1344
VL - 6
SP - 61
EP - 68
JO - Journal of Photochemistry and Photobiology B: Biology
JF - Journal of Photochemistry and Photobiology B: Biology
IS - 1-2
ER -