Cellular thymidine kinase activity is required for the inhibition of HIV- 1 replication by AZT in lymphocytes

Israel Lowy; Manuel Caruso; Stephen P. Goff; David Klatzmann

doi:10.1006/viro.1994.1185

Cellular thymidine kinase activity is required for the inhibition of HIV- 1 replication by AZT in lymphocytes

Israel Lowy
, Manuel Caruso
, Stephen P. Goff
, David Klatzmann

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In this report, we provide evidence that the cellular thymidine kinase activity is required for the inhibition of HIV replication by zidovudine (AZT) in lymphocytes. The HSV-1 thymidine kinase protein is not able to substitute for the cellular enzyme, in accord with in vitro data that AZT is poorly phosphorylated by the HSV-derived activity.

Original language	English
Article number	71185
Pages (from-to)	271-275
Number of pages	5
Journal	Virology
Volume	200
Issue number	1
DOIs	https://doi.org/10.1006/viro.1994.1185
State	Published - Apr 1994
Externally published	Yes

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10.1006/viro.1994.1185

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title = "Cellular thymidine kinase activity is required for the inhibition of HIV- 1 replication by AZT in lymphocytes",

abstract = "In this report, we provide evidence that the cellular thymidine kinase activity is required for the inhibition of HIV replication by zidovudine (AZT) in lymphocytes. The HSV-1 thymidine kinase protein is not able to substitute for the cellular enzyme, in accord with in vitro data that AZT is poorly phosphorylated by the HSV-derived activity.",

author = "Israel Lowy and Manuel Caruso and Goff, \{Stephen P.\} and David Klatzmann",

year = "1994",

month = apr,

doi = "10.1006/viro.1994.1185",

language = "English",

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journal = "Virology",

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T1 - Cellular thymidine kinase activity is required for the inhibition of HIV- 1 replication by AZT in lymphocytes

AU - Lowy, Israel

AU - Caruso, Manuel

AU - Goff, Stephen P.

AU - Klatzmann, David

PY - 1994/4

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AB - In this report, we provide evidence that the cellular thymidine kinase activity is required for the inhibition of HIV replication by zidovudine (AZT) in lymphocytes. The HSV-1 thymidine kinase protein is not able to substitute for the cellular enzyme, in accord with in vitro data that AZT is poorly phosphorylated by the HSV-derived activity.

UR - https://www.scopus.com/pages/publications/0028336630

U2 - 10.1006/viro.1994.1185

DO - 10.1006/viro.1994.1185

M3 - Article

AN - SCOPUS:0028336630

SN - 0042-6822

VL - 200

SP - 271

EP - 275

JO - Virology

JF - Virology

IS - 1

M1 - 71185

ER -

Cellular thymidine kinase activity is required for the inhibition of HIV- 1 replication by AZT in lymphocytes

Abstract

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