Cellular thymidine kinase activity is required for the inhibition of HIV- 1 replication by AZT in lymphocytes

Israel Lowy, Manuel Caruso, Stephen P. Goff, David Klatzmann

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In this report, we provide evidence that the cellular thymidine kinase activity is required for the inhibition of HIV replication by zidovudine (AZT) in lymphocytes. The HSV-1 thymidine kinase protein is not able to substitute for the cellular enzyme, in accord with in vitro data that AZT is poorly phosphorylated by the HSV-derived activity.

Original languageEnglish
Article number71185
Pages (from-to)271-275
Number of pages5
JournalVirology
Volume200
Issue number1
DOIs
StatePublished - Apr 1994
Externally publishedYes

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