Cellular Therapy in Pediatric Hematologic Malignancies

Susan Kuldanek; Bryce Pasko; Melkon DomBourian; Kyle Annen

doi:10.1016/j.cll.2020.10.008

Cellular Therapy in Pediatric Hematologic Malignancies

Susan Kuldanek, Bryce Pasko, Melkon DomBourian, Kyle Annen

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Advances in cellular therapies for pediatric patients have created many opportunities for improved survival with reduced morbidity. This article reviews current cellular therapies in pediatric hematological malignancy, including the most updated practices in hematopoietic stem cell transplant and the use of chimeric antigen receptor (CAR) therapy in T cells. Hematopoietic stem cell transplant has evolved with improvements in chemotherapy regimens, immunosuppression, and donor-matching options. Novel therapies in development which will likely further improve the options for patients are reviewed including Natural Killer, Regulatory T-cells and αβ depletion.

Original language	English
Pages (from-to)	121-132
Number of pages	12
Journal	Clinics in Laboratory Medicine
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.cll.2020.10.008
State	Published - Mar 2021
Externally published	Yes

Keywords

CAR T cell
Cord blood expansion
HPSC
NK cell therapy
Pediatric
Regulatory

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10.1016/j.cll.2020.10.008

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title = "Cellular Therapy in Pediatric Hematologic Malignancies",

abstract = "Advances in cellular therapies for pediatric patients have created many opportunities for improved survival with reduced morbidity. This article reviews current cellular therapies in pediatric hematological malignancy, including the most updated practices in hematopoietic stem cell transplant and the use of chimeric antigen receptor (CAR) therapy in T cells. Hematopoietic stem cell transplant has evolved with improvements in chemotherapy regimens, immunosuppression, and donor-matching options. Novel therapies in development which will likely further improve the options for patients are reviewed including Natural Killer, Regulatory T-cells and αβ depletion.",

keywords = "CAR T cell, Cord blood expansion, HPSC, NK cell therapy, Pediatric, Regulatory",

author = "Susan Kuldanek and Bryce Pasko and Melkon DomBourian and Kyle Annen",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = mar,

doi = "10.1016/j.cll.2020.10.008",

language = "English",

volume = "41",

pages = "121--132",

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TY - JOUR

T1 - Cellular Therapy in Pediatric Hematologic Malignancies

AU - Kuldanek, Susan

AU - Pasko, Bryce

AU - DomBourian, Melkon

AU - Annen, Kyle

PY - 2021/3

Y1 - 2021/3

N2 - Advances in cellular therapies for pediatric patients have created many opportunities for improved survival with reduced morbidity. This article reviews current cellular therapies in pediatric hematological malignancy, including the most updated practices in hematopoietic stem cell transplant and the use of chimeric antigen receptor (CAR) therapy in T cells. Hematopoietic stem cell transplant has evolved with improvements in chemotherapy regimens, immunosuppression, and donor-matching options. Novel therapies in development which will likely further improve the options for patients are reviewed including Natural Killer, Regulatory T-cells and αβ depletion.

AB - Advances in cellular therapies for pediatric patients have created many opportunities for improved survival with reduced morbidity. This article reviews current cellular therapies in pediatric hematological malignancy, including the most updated practices in hematopoietic stem cell transplant and the use of chimeric antigen receptor (CAR) therapy in T cells. Hematopoietic stem cell transplant has evolved with improvements in chemotherapy regimens, immunosuppression, and donor-matching options. Novel therapies in development which will likely further improve the options for patients are reviewed including Natural Killer, Regulatory T-cells and αβ depletion.

KW - CAR T cell

KW - Cord blood expansion

KW - HPSC

KW - NK cell therapy

KW - Pediatric

KW - Regulatory

UR - http://www.scopus.com/inward/record.url?scp=85099641441&partnerID=8YFLogxK

U2 - 10.1016/j.cll.2020.10.008

DO - 10.1016/j.cll.2020.10.008

M3 - Review article

C2 - 33494880

AN - SCOPUS:85099641441

SN - 0272-2712

VL - 41

SP - 121

EP - 132

JO - Clinics in Laboratory Medicine

JF - Clinics in Laboratory Medicine

IS - 1

ER -

Cellular Therapy in Pediatric Hematologic Malignancies

Abstract

Keywords

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