Cellular Therapy in Pediatric Hematologic Malignancies

Susan Kuldanek, Bryce Pasko, Melkon DomBourian, Kyle Annen

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Advances in cellular therapies for pediatric patients have created many opportunities for improved survival with reduced morbidity. This article reviews current cellular therapies in pediatric hematological malignancy, including the most updated practices in hematopoietic stem cell transplant and the use of chimeric antigen receptor (CAR) therapy in T cells. Hematopoietic stem cell transplant has evolved with improvements in chemotherapy regimens, immunosuppression, and donor-matching options. Novel therapies in development which will likely further improve the options for patients are reviewed including Natural Killer, Regulatory T-cells and αβ depletion.

Original languageEnglish
Pages (from-to)121-132
Number of pages12
JournalClinics in Laboratory Medicine
Issue number1
StatePublished - Mar 2021
Externally publishedYes


  • CAR T cell
  • Cord blood expansion
  • HPSC
  • NK cell therapy
  • Pediatric
  • Regulatory


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