Cellular retinoid binding proteins

Johan Sundelin; Ulf Eriksson; Håkan Melhus; Magnus Nilsson; Joakim Lundvall; Claes Olof Båvik; Eva Hansson; Brehon Laurent; Per A. Peterson

doi:10.1016/0009-3084(85)90065-9

Cellular retinoid binding proteins

Johan Sundelin
, Ulf Eriksson
, Håkan Melhus
, Magnus Nilsson
, Joakim Lundvall
, Claes Olof Båvik
, Eva Hansson
, Brehon Laurent
, Per A. Peterson

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The cellular retinol-binding protein (CRBP) and the cellular retinoic acid binding protein (CRABP) have similar physicochemical characteristics. The amino acid sequences of rat CRBP and bovine CRABP have been elucidated and they display 40% sequence identity. Both protein sequences appear to be evolutionarily highly conserved. The amino acid sequence of human CRBP, deduced from a cDNA-clone, is 96% identical to the rat CRBP sequence. CRBP and CRABP are members of a protein family, all members of which may bind hydrophobic ligands and interact with membrane components. All members of the protein family are probably related in tertiary structure and might interact with membrane components through two regions with a high probability for α-helix. The tissue distribution of CRBP and CRABP, together with their relation to lipid transporting proteins suggests that CRBP and CRABP are cellular transporting proteins for retinol and retinoic acid, respectively.

Original language	English
Pages (from-to)	175-185
Number of pages	11
Journal	Chemistry and Physics of Lipids
Volume	38
Issue number	1-2
DOIs	https://doi.org/10.1016/0009-3084(85)90065-9
State	Published - 30 Aug 1985
Externally published	Yes

Keywords

cellular retinoic acid binding protein
cellular retinol-binding protein
sequence homology
transport
vitamin A

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10.1016/0009-3084(85)90065-9

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@article{01713a96b72f480fb804a5db81734aac,

title = "Cellular retinoid binding proteins",

abstract = "The cellular retinol-binding protein (CRBP) and the cellular retinoic acid binding protein (CRABP) have similar physicochemical characteristics. The amino acid sequences of rat CRBP and bovine CRABP have been elucidated and they display 40\% sequence identity. Both protein sequences appear to be evolutionarily highly conserved. The amino acid sequence of human CRBP, deduced from a cDNA-clone, is 96\% identical to the rat CRBP sequence. CRBP and CRABP are members of a protein family, all members of which may bind hydrophobic ligands and interact with membrane components. All members of the protein family are probably related in tertiary structure and might interact with membrane components through two regions with a high probability for α-helix. The tissue distribution of CRBP and CRABP, together with their relation to lipid transporting proteins suggests that CRBP and CRABP are cellular transporting proteins for retinol and retinoic acid, respectively.",

keywords = "cellular retinoic acid binding protein, cellular retinol-binding protein, sequence homology, transport, vitamin A",

author = "Johan Sundelin and Ulf Eriksson and H{\aa}kan Melhus and Magnus Nilsson and Joakim Lundvall and B{\aa}vik, \{Claes Olof\} and Eva Hansson and Brehon Laurent and Peterson, \{Per A.\}",

note = "Funding Information: This work was supportedby a grant from the SwedishM edicalR esearchC ouncil.",

year = "1985",

month = aug,

day = "30",

doi = "10.1016/0009-3084(85)90065-9",

language = "English",

volume = "38",

pages = "175--185",

journal = "Chemistry and Physics of Lipids",

issn = "0009-3084",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Cellular retinoid binding proteins

AU - Sundelin, Johan

AU - Eriksson, Ulf

AU - Melhus, Håkan

AU - Nilsson, Magnus

AU - Lundvall, Joakim

AU - Båvik, Claes Olof

AU - Hansson, Eva

AU - Laurent, Brehon

AU - Peterson, Per A.

N1 - Funding Information: This work was supportedby a grant from the SwedishM edicalR esearchC ouncil.

PY - 1985/8/30

Y1 - 1985/8/30

N2 - The cellular retinol-binding protein (CRBP) and the cellular retinoic acid binding protein (CRABP) have similar physicochemical characteristics. The amino acid sequences of rat CRBP and bovine CRABP have been elucidated and they display 40% sequence identity. Both protein sequences appear to be evolutionarily highly conserved. The amino acid sequence of human CRBP, deduced from a cDNA-clone, is 96% identical to the rat CRBP sequence. CRBP and CRABP are members of a protein family, all members of which may bind hydrophobic ligands and interact with membrane components. All members of the protein family are probably related in tertiary structure and might interact with membrane components through two regions with a high probability for α-helix. The tissue distribution of CRBP and CRABP, together with their relation to lipid transporting proteins suggests that CRBP and CRABP are cellular transporting proteins for retinol and retinoic acid, respectively.

AB - The cellular retinol-binding protein (CRBP) and the cellular retinoic acid binding protein (CRABP) have similar physicochemical characteristics. The amino acid sequences of rat CRBP and bovine CRABP have been elucidated and they display 40% sequence identity. Both protein sequences appear to be evolutionarily highly conserved. The amino acid sequence of human CRBP, deduced from a cDNA-clone, is 96% identical to the rat CRBP sequence. CRBP and CRABP are members of a protein family, all members of which may bind hydrophobic ligands and interact with membrane components. All members of the protein family are probably related in tertiary structure and might interact with membrane components through two regions with a high probability for α-helix. The tissue distribution of CRBP and CRABP, together with their relation to lipid transporting proteins suggests that CRBP and CRABP are cellular transporting proteins for retinol and retinoic acid, respectively.

KW - cellular retinoic acid binding protein

KW - cellular retinol-binding protein

KW - sequence homology

KW - transport

KW - vitamin A

UR - https://www.scopus.com/pages/publications/0022416954

U2 - 10.1016/0009-3084(85)90065-9

DO - 10.1016/0009-3084(85)90065-9

M3 - Article

C2 - 2998635

AN - SCOPUS:0022416954

SN - 0009-3084

VL - 38

SP - 175

EP - 185

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

IS - 1-2

ER -

Cellular retinoid binding proteins

Abstract

Keywords

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