TY - JOUR
T1 - Cellular response to DNA damage.
AU - Kao, Johnny
AU - Rosenstein, Barry S.
AU - Peters, Sheila
AU - Milano, Michael T.
AU - Kron, Stephen J.
PY - 2006/3/1
Y1 - 2006/3/1
N2 - Eukaryotic cells, from yeast to man, possess evolutionarily conserved mechanisms to accurately and efficiently repair the overwhelming majority of DNA damage, thereby ensuring genomic integrity. Important repair pathways include base excision repair, nucleotide excision repair, mismatch repair, non-homologous end-joining, and homologous recombination. Defects in DNA repair processes generally result in susceptibility to cancer and, often, abnormalities in multiple organ systems. While signal transduction pathways have been intensely studied, epigenetic changes occurring in response to DNA damage are rapidly increasing in importance. Effective radiation and chemotherapy sensitization could result from selective inhibition of DNA repair in tumor cells. DNA damage repair is a dynamic field of research where the fruits of basic research often have important clinical implications.
AB - Eukaryotic cells, from yeast to man, possess evolutionarily conserved mechanisms to accurately and efficiently repair the overwhelming majority of DNA damage, thereby ensuring genomic integrity. Important repair pathways include base excision repair, nucleotide excision repair, mismatch repair, non-homologous end-joining, and homologous recombination. Defects in DNA repair processes generally result in susceptibility to cancer and, often, abnormalities in multiple organ systems. While signal transduction pathways have been intensely studied, epigenetic changes occurring in response to DNA damage are rapidly increasing in importance. Effective radiation and chemotherapy sensitization could result from selective inhibition of DNA repair in tumor cells. DNA damage repair is a dynamic field of research where the fruits of basic research often have important clinical implications.
UR - http://www.scopus.com/inward/record.url?scp=33749072970&partnerID=8YFLogxK
U2 - 10.1196/annals.1363.012
DO - 10.1196/annals.1363.012
M3 - Review article
C2 - 16533929
AN - SCOPUS:33749072970
SN - 0077-8923
VL - 1066
SP - 243
EP - 258
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -