Cellular regulation of the structure and function of aortic valves

Ismail El-Hamamsy, Adrian H. Chester, Magdi H. Yacoub

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


The aortic valve was long considered a passive structure that opens and closes in response to changes in transvalvular pressure. Recent evidence suggests that the aortic valve performs highly sophisticated functions as a result of its unique microscopic structure. These functions allow it to adapt to its hemodynamic and mechanical environment. Understanding the cellular and molecular mechanisms involved in normal valve physiology is essential to elucidate the mechanisms behind valve disease. We here review the structure and developmental biology of aortic valves; we examine the role of its cellular parts in regulating its function and describe potential pathophysiological and clinical implications.

Original languageEnglish
Pages (from-to)5-12
Number of pages8
JournalJournal of Advanced Research
Issue number1
StatePublished - Jan 2010
Externally publishedYes


  • Aortic valve
  • Aortic valve calcification
  • Endothelium
  • Interstitial cells
  • Mechanotransduction


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