Cellular localization of [3H]-diazepam receptors

F. A. Henn; D. J. Henke

doi:10.1016/0028-3908(78)90143-0

Cellular localization of [³H]-diazepam receptors

F. A. Henn
, D. J. Henke

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Isolated fractions enriched in bovine cortical astroglial cells or nerve endings were used to determine the receptor site for [³H]-diazepam binding. The results suggest strong enrichment in glial cells for the benzodiazepine receptor. Both the inhibition of diazepam binding by other benzodiazepines and the affinity of the glial receptor for diazepam suggest that this receptor is similar to that previously reported in crude CNS membrane fractions.

Original language	English
Pages (from-to)	985-988
Number of pages	4
Journal	Neuropharmacology
Volume	17
Issue number	11
DOIs	https://doi.org/10.1016/0028-3908(78)90143-0
State	Published - Nov 1978
Externally published	Yes

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title = "Cellular localization of [3H]-diazepam receptors",

abstract = "Isolated fractions enriched in bovine cortical astroglial cells or nerve endings were used to determine the receptor site for [3H]-diazepam binding. The results suggest strong enrichment in glial cells for the benzodiazepine receptor. Both the inhibition of diazepam binding by other benzodiazepines and the affinity of the glial receptor for diazepam suggest that this receptor is similar to that previously reported in crude CNS membrane fractions.",

author = "Henn, \{F. A.\} and Henke, \{D. J.\}",

year = "1978",

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AU - Henn, F. A.

AU - Henke, D. J.

PY - 1978/11

Y1 - 1978/11

N2 - Isolated fractions enriched in bovine cortical astroglial cells or nerve endings were used to determine the receptor site for [3H]-diazepam binding. The results suggest strong enrichment in glial cells for the benzodiazepine receptor. Both the inhibition of diazepam binding by other benzodiazepines and the affinity of the glial receptor for diazepam suggest that this receptor is similar to that previously reported in crude CNS membrane fractions.

AB - Isolated fractions enriched in bovine cortical astroglial cells or nerve endings were used to determine the receptor site for [3H]-diazepam binding. The results suggest strong enrichment in glial cells for the benzodiazepine receptor. Both the inhibition of diazepam binding by other benzodiazepines and the affinity of the glial receptor for diazepam suggest that this receptor is similar to that previously reported in crude CNS membrane fractions.

UR - https://www.scopus.com/pages/publications/0018196929

U2 - 10.1016/0028-3908(78)90143-0

DO - 10.1016/0028-3908(78)90143-0

M3 - Article

C2 - 724102

AN - SCOPUS:0018196929

SN - 0028-3908

VL - 17

SP - 985

EP - 988

JO - Neuropharmacology

JF - Neuropharmacology

IS - 11

ER -

Cellular localization of [3H]-diazepam receptors

Abstract

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Cellular localization of [³H]-diazepam receptors