Cellular immune responses against CT7 (MAGE-C1) and humoral responses against other cancer-testis antigens in multiple myeloma patients

Nikoletta Lendvai, Sacha Gnjatic, Erika Ritter, Michael Mangone, Wayne Austin, Karina Reyner, David Jayabalan, Ruben Niesvizky, Sundar Jagannath, Nina Bhardwaj, Selina Chen-Kiang, Lloyd J. Old, Hearn Jay Cho

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The type I melanoma antigen gene (MAGE) proteins CT7 (MAGE-C1) and MAGE-A3 are commonly expressed in multiple myeloma (MM), and their expression correlates with increased plasma cell proliferation and poor clinical outcome. They belong to the cancertestis antigen (CTAg) group of tumor-associated proteins, some of which elicit spontaneous immune responses in cancer patients. CT7 and MAGE-A3 are promising antigenic targets for therapeutic tumor vaccines in myeloma; therefore, it is critical to determine if they are immunogenic in MM patients. We analyzed cellular and humoral immune responses against CTAgs in patients with plasma cell dyscrasias: MM, monoclonal gammopathy of undetermined significance (MGUS), and Waldenström's macroglobulinemia (WM). Bone marrow lymphocytes from two of four untreated MM patients exhibited CT7-specific cellular immune responses as measured by an autologous cellular immunity assay, the first such immune response to CT7 to be reported in cancer patients. Sera from 24 patients were screened by ELISA for humoral immune responses to CTAgs. Two patients with MM demonstrated positive titers, one for MAGE-A1 and the other for SSX1. These data demonstrate that CTAgs, particularly CT7, are immunogenic in MM patients and merit further exploration as targets of immunological therapy in MM.

Original languageEnglish
JournalCancer Immunity
Volume10
StatePublished - 29 Jan 2010
Externally publishedYes

Keywords

  • CT antigens
  • Cellular immunity
  • Human
  • Humoral immunity
  • Multiple myeloma

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