Cellular and molecular modulation of rotator cuff muscle pathophysiology

Chengcheng Fu, Alice H. Huang, Leesa M. Galatz, Woojin M. Han

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Rotator cuff (RC) tendon tears are common shoulder injuries that result in irreversible and persistent degeneration of the associated muscles, which is characterized by severe inflammation, atrophy, fibrosis, and fatty infiltration. Although RC muscle degeneration strongly dictates the overall clinical outcomes, strategies to stimulate RC muscle regeneration have largely been overlooked to date. In this review, we highlight the current understanding of the cellular processes that coordinate muscle regeneration, and the roles of muscle resident cells, including immune cells, fibroadipogenic progenitors, and muscle satellite cells in the pathophysiologic regulation of RC muscles following injury. This review also provides perspectives for potential therapies to alleviate the hallmarks of RC muscle degeneration to address current limitations in postsurgical recovery.

Original languageEnglish
Pages (from-to)2310-2322
Number of pages13
JournalJournal of Orthopaedic Research
Volume39
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • atrophy
  • fatty infiltration
  • fibrosis
  • muscle
  • rotator cuff

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