Cellular and Humoral Responses Follow-up for 8 Months after Vaccination with mRNA-Based Anti-SARS-CoV-2 Vaccines

Sergio Gil-Manso, Diego Carbonell, Verónica Astrid Pérez-Fernández, Rocío López-Esteban, Roberto Alonso, Patricia Muñoz, Jordi Ochando, Ignacio Sánchez-Arcilla, Jose M. Bellón, Rafael Correa-Rocha, Marjorie Pion

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Vaccination against SARS-CoV-2 has become the main method of reducing mortality and severity of COVID-19. This work aims to study the evolution of the cellular and humoral responses conferred by two mRNA vaccines after two doses against SARS-CoV-2. On days 30 and 240 after the second dose of both vaccines, the anti-S antibodies in plasma were evaluated from 82 volunteers vaccinated with BNT162b2 and 68 vaccinated with mRNA-1273. Peripheral blood was stimulated with peptides encompassing the entire SARS-CoV-2 Spike sequence. IgG Anti-S antibodies (humoral) were quantified on plasma, and inflammatory cytokines (cellular) were measured after stimulation. We observed a higher response (both humoral and cellular) with the mRNA-1273 vaccine. Stratifying by age and gender, differences between vaccines were observed, especially in women under 48 and men over 48 years old. Therefore, this work could help to set up a vaccination strategy that could be applied to confer maximum immunity.

Original languageEnglish
Article number1676
JournalBiomedicines
Volume10
Issue number7
DOIs
StatePublished - Jul 2022

Keywords

  • COVID-19
  • SARS-CoV-2
  • cellular responses
  • humoral responses
  • mRNA-vaccines

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