Cell-seeding techniques in vascular tissue engineering

Gustavo A. Villalona, Brooks Udelsman, Daniel R. Duncan, Edward McGillicuddy, Rajendra F. Sawh-Martinez, Narutoshi Hibino, Christopher Painter, Tamar Mirensky, Benjamin Erickson, Toshiharu Shinoka, Christopher K. Breuer

Research output: Contribution to journalReview articlepeer-review

188 Scopus citations

Abstract

Previous studies have demonstrated the benefits of cell seeding in the construction of tissue-engineered vascular grafts (TEVG). However, seeding methods are diverse and no method is clearly superior in either promoting seeding efficiency or improving long-term graft function. As we head into an era during which a variety of different TEVG are under investigation in clinical trials around the world, it is important to consider the regulatory issues surrounding the translation of these technologies. In this review, we summarize important advances in the field of vascular tissue engineering, with particular attention on cell-seeding techniques for TEVG development and special emphasis placed on regulatory issues concerning the clinical translation of these various methods.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalTissue Engineering - Part B: Reviews
Volume16
Issue number3
DOIs
StatePublished - 1 Jun 2010
Externally publishedYes

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