TY - JOUR
T1 - Cell-seeding techniques in vascular tissue engineering
AU - Villalona, Gustavo A.
AU - Udelsman, Brooks
AU - Duncan, Daniel R.
AU - McGillicuddy, Edward
AU - Sawh-Martinez, Rajendra F.
AU - Hibino, Narutoshi
AU - Painter, Christopher
AU - Mirensky, Tamar
AU - Erickson, Benjamin
AU - Shinoka, Toshiharu
AU - Breuer, Christopher K.
PY - 2010/6/1
Y1 - 2010/6/1
N2 - Previous studies have demonstrated the benefits of cell seeding in the construction of tissue-engineered vascular grafts (TEVG). However, seeding methods are diverse and no method is clearly superior in either promoting seeding efficiency or improving long-term graft function. As we head into an era during which a variety of different TEVG are under investigation in clinical trials around the world, it is important to consider the regulatory issues surrounding the translation of these technologies. In this review, we summarize important advances in the field of vascular tissue engineering, with particular attention on cell-seeding techniques for TEVG development and special emphasis placed on regulatory issues concerning the clinical translation of these various methods.
AB - Previous studies have demonstrated the benefits of cell seeding in the construction of tissue-engineered vascular grafts (TEVG). However, seeding methods are diverse and no method is clearly superior in either promoting seeding efficiency or improving long-term graft function. As we head into an era during which a variety of different TEVG are under investigation in clinical trials around the world, it is important to consider the regulatory issues surrounding the translation of these technologies. In this review, we summarize important advances in the field of vascular tissue engineering, with particular attention on cell-seeding techniques for TEVG development and special emphasis placed on regulatory issues concerning the clinical translation of these various methods.
UR - http://www.scopus.com/inward/record.url?scp=77952920902&partnerID=8YFLogxK
U2 - 10.1089/ten.teb.2009.0527
DO - 10.1089/ten.teb.2009.0527
M3 - Review article
C2 - 20085439
AN - SCOPUS:77952920902
SN - 1937-3368
VL - 16
SP - 341
EP - 350
JO - Tissue Engineering - Part B: Reviews
JF - Tissue Engineering - Part B: Reviews
IS - 3
ER -