Cell-mediated immunity in patients with ovarian carcinoma

Shin Yee Chen, David Koffler, Carmel J. Cohen

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Eight patients with serous or mucinous cystadenocarcinoma were tested for cellular hypersensitivity to tumor antigens by a leukocyte migration test. Inhibition of leukocyte migration with autologous tumor was noted in all patients. Leukocytes from 5 of 7 patients studied showed cross-inhibition by serous or mucinous carcinoma. Inhibition by homologous serous cystadenocarcinoma was observed in 2 patients. In contrast, squamous cell carcinoma, leiomyosarcoma, and mixed mesodermal tumors of the uterus did not inhibit leukocyte migration from patients with ovarian carcinoma. These results indicate that a leukocyte migration test is capable of detecting cellular hypersensitivity in patients with ovarian carcinoma and that common tumor antigens are present in serous and mucinous cystadenocarcinomas of the ovary.

Original languageEnglish
Pages (from-to)467-470
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume115
Issue number4
DOIs
StatePublished - 15 Feb 1973

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