Cell-context specific role of the E2F/Rb pathway in development and disease

Victoria A. Swiss, Patrizia Casaccia

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Development of the central nervous system (CNS) requires the generation of neuronal and glial cell subtypes in appropriate numbers, and this demands the careful coordination of cell-cycle exit, survival, and differentiation. The E2F/Rb pathway is critical for cell-cycle regulation and also modulates survival and differentiation of distinct cell types in the developing and adult CNS. In this review, we first present the specific temporal patterns of expression of the E2F and Rb family members during CNS development and then discuss the genetic ablation of single or multiple members of these two families. Overall, the available data suggest a time-dependent and cell-context specific role of E2F and Rb family members in the developing and adult CNS.

Original languageEnglish
Pages (from-to)377-390
Number of pages14
JournalGLIA
Volume58
Issue number4
DOIs
StatePublished - Mar 2010
Externally publishedYes

Keywords

  • Brain
  • Cell cycle
  • Differentiation
  • Glia
  • Proliferation
  • Tumor

Fingerprint

Dive into the research topics of 'Cell-context specific role of the E2F/Rb pathway in development and disease'. Together they form a unique fingerprint.

Cite this