Cell Biology: ERADicating Survival with BOK

Jerry Edward Chipuk, Mark P. Luna-Vargas

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations


Mechanistic insights into the function of the pro-apoptotic BCL-2 family member BOK have remained elusive. A recent study shows that healthy cells constitutively degrade BOK via the ER-associated degradation and ubiquitin–proteasome pathways; following proteasome inhibition, BOK is stabilized to initiate a unique pro-apoptotic death program.

Original languageEnglish
Pages (from-to)R473-R476
JournalCurrent Biology
Issue number11
StatePublished - 2016


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