@article{6b0b922f37e34095bc55beb870b8dbe4,
title = "CDK4: a master regulator of the cell cycle and its role in cancer",
abstract = "The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G1 phase when the cell prepares to initiate DNA synthesis. Although Cdk4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer. This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 inhibitors that are currently being used as cancer therapeutics.",
keywords = "CDK4/6, cancer, cell cycle, checkpoint inhibitor, targeted therapy",
author = "Baker, {Stacey J.} and Poulikakos, {Poulikos I.} and Irie, {Hanna Y.} and Samir Parekh and Reddy, {E. Premkumar}",
note = "Funding Information: P.I.P is supported by grants from the National Institutes of Health (NIH) and National Cancer Institute (NCI) (R01 CA204314, R01 CA240362, and R01 CA238229), the Irma T. Hirschl Trust, the Manhasset Women{\textquoteright}s Coalition Against Breast Cancer, the Breast Cancer Alliance, the Melanoma Research Foundation, the Melanoma Research Alliance and Tisch Cancer Institute (TCI) developmental awards. H.Y.I. is supported by grants from the American Cancer Society (ACS) and the Breast Cancer Research Foundation (BCRF). S.P. is supported by the NCI (R01CA244899 and R01 CA252222) and receives research funding from Amgen, Bristol Myers Squibb and Karyopharm. E.P.R is supported by a grant from the NIH/ NCI (RO1 CA251448). Publisher Copyright: {\textcopyright} 2022 Baker et al.",
year = "2022",
doi = "10.18632/genesandcancer.221",
language = "English",
volume = "13",
pages = "21--45",
journal = "Genes and Cancer",
issn = "1947-6019",
publisher = "SAGE Publications Inc.",
}