126 Scopus citations


The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G1 phase when the cell prepares to initiate DNA synthesis. Although CDK4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer. This review discusses the role that CDK4 plays in cell cycle control, normal development, and tumorigenesis as well as how small molecule inhibitors of CDK4 can be used to treat disease.

Original languageEnglish
Pages (from-to)658-669
Number of pages12
JournalGenes and Cancer
Issue number11-12
StatePublished - 1 Nov 2012


  • CDK4
  • Cancer
  • Cell cycle
  • Knockout
  • Targeted therapy


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