CDK4: A key player in the cell cycle, development, and cancer

Stacey J. Baker; E. Premkumar Reddy

doi:10.1177/1947601913478972

CDK4: A key player in the cell cycle, development, and cancer

Stacey J. Baker, E. Premkumar Reddy

Research output: Contribution to journal › Review article › peer-review

153 Scopus citations

Abstract

The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G₁ phase when the cell prepares to initiate DNA synthesis. Although CDK4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer. This review discusses the role that CDK4 plays in cell cycle control, normal development, and tumorigenesis as well as how small molecule inhibitors of CDK4 can be used to treat disease.

Original language	English
Pages (from-to)	658-669
Number of pages	12
Journal	Genes and Cancer
Volume	3
Issue number	11-12
DOIs	https://doi.org/10.1177/1947601913478972
State	Published - 1 Nov 2012

Keywords

CDK4
Cancer
Cell cycle
Knockout
Targeted therapy

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title = "CDK4: A key player in the cell cycle, development, and cancer",

abstract = "The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G1 phase when the cell prepares to initiate DNA synthesis. Although CDK4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer. This review discusses the role that CDK4 plays in cell cycle control, normal development, and tumorigenesis as well as how small molecule inhibitors of CDK4 can be used to treat disease.",

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T1 - CDK4

T2 - A key player in the cell cycle, development, and cancer

AU - Baker, Stacey J.

AU - Reddy, E. Premkumar

PY - 2012/11/1

Y1 - 2012/11/1

N2 - The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G1 phase when the cell prepares to initiate DNA synthesis. Although CDK4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer. This review discusses the role that CDK4 plays in cell cycle control, normal development, and tumorigenesis as well as how small molecule inhibitors of CDK4 can be used to treat disease.

AB - The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G1 phase when the cell prepares to initiate DNA synthesis. Although CDK4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer. This review discusses the role that CDK4 plays in cell cycle control, normal development, and tumorigenesis as well as how small molecule inhibitors of CDK4 can be used to treat disease.

KW - CDK4

KW - Cancer

KW - Cell cycle

KW - Knockout

KW - Targeted therapy

UR - http://www.scopus.com/inward/record.url?scp=84880481139&partnerID=8YFLogxK

U2 - 10.1177/1947601913478972

DO - 10.1177/1947601913478972

M3 - Review article

AN - SCOPUS:84880481139

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VL - 3

SP - 658

EP - 669

JO - Genes and Cancer

JF - Genes and Cancer

IS - 11-12

ER -

CDK4: A key player in the cell cycle, development, and cancer

Abstract

Keywords

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