TY - JOUR
T1 - CD5 negative, cyclin D1-positive diffuse large B-cell lymphoma (DLBCL) presenting as ruptured spleen
AU - Teruya-Feldstein, Julie
AU - Gopalan, Anuradha
AU - Moskowitz, Craig H.
PY - 2009/5
Y1 - 2009/5
N2 - We present a case of diffuse large B-cell lymphoma CD5 negative, Cyclin D1 positive presenting as ruptured spleen in a 63-year-old man requiring emergent splenectomy. Tumor cells showed marked pleomorphism, anaplasia, and increased mitotic figures with positive Cyclin D1, BCL6, MUM1, P53, and a high MIB1 proliferative fraction. The patient received multiple therapies and ultimately died. This case raises the differential diagnoses of pleomorphic mantle cell lymphoma and other aggressive lymphomas with pleomorphic, anaplastic, and Reed-Sternberg-like cells.
AB - We present a case of diffuse large B-cell lymphoma CD5 negative, Cyclin D1 positive presenting as ruptured spleen in a 63-year-old man requiring emergent splenectomy. Tumor cells showed marked pleomorphism, anaplasia, and increased mitotic figures with positive Cyclin D1, BCL6, MUM1, P53, and a high MIB1 proliferative fraction. The patient received multiple therapies and ultimately died. This case raises the differential diagnoses of pleomorphic mantle cell lymphoma and other aggressive lymphomas with pleomorphic, anaplastic, and Reed-Sternberg-like cells.
KW - CD5 negative
KW - Cyclin D1-positive DLBCL
KW - Pleomorphic mantle cell lymphoma
KW - Splenic rupture
UR - http://www.scopus.com/inward/record.url?scp=66549097996&partnerID=8YFLogxK
U2 - 10.1097/PAI.0b013e318182d2aa
DO - 10.1097/PAI.0b013e318182d2aa
M3 - Article
C2 - 18838919
AN - SCOPUS:66549097996
SN - 1541-2016
VL - 17
SP - 255
EP - 258
JO - Applied Immunohistochemistry and Molecular Morphology
JF - Applied Immunohistochemistry and Molecular Morphology
IS - 3
ER -