CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients

Hiroyoshi Nishikawa, Elke Jäger, Gerd Ritter, Lloyd J. Old, Sacha Gnjatic

Research output: Contribution to journalArticlepeer-review

156 Scopus citations

Abstract

A proportion of cancer patients naturally develop CD4+ T-helper type 1 (Th1) cell responses to NY-ESO-1 that correlate with anti-NY-ESO-1 serum antibodies. To address the role of T-cell regulation in the control of spontaneous tumor immunity, we analyzed NY-ESO-1-specific Th1 cell induction before or after depletion of CD4+CD25+ T cells in vitro. While Th1 cells were generated in the presence of CD25+ T cells in cancer patients seropositive for NY-ESO-1, seronegative cancer patients and healthy donors required CD25+ T-cell depletion for in vitro induction of NY-ESO-1-specific Th1 cells. In vitro, newly generated NY-ESO-1-specific Th1 cells were derived from naive precursors, whereas preexisting memory populations were detectable exclusively in patients with NY-ESO-1 antibody. Memory populations were less sensitive than naive populations to CD4 +CD25+ regulatory T cells. We propose that CD4 +CD25+ regulatory T cells are involved in the generation and regulation of NY-ESO-1-specific antitumor immunity.

Original languageEnglish
Pages (from-to)1008-1011
Number of pages4
JournalBlood
Volume106
Issue number3
DOIs
StatePublished - 1 Aug 2005
Externally publishedYes

Fingerprint

Dive into the research topics of 'CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients'. Together they form a unique fingerprint.

Cite this