Overexpression of HOXA9 is linked to the molecular pathogenesis of acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS), conferring a poor prognosis. HOXA9 expression levels were analysed in the diagnostic bone marrow (BM) samples of 13 MDS patients. HOXA9 was expressed by CD34+ BM cells at median levels 3.1-fold higher than in CD34- cells from the same patient and at median levels 4.3-fold higher than in CD34+ cells from healthy donors. These results indicate that CD34+ cell selection is required to accurately assess the expression levels of HOXA9 and related genes in the multipotential malignant progenitor cells of MDS patients.
- Myelodysplastic syndrome