Objective. - To determine the prevalence and clinical significance of a follicular origin in primary intestinal large B-cell lymphomas. Design. - We performed immunohistochemistry for detection of CD10 and Bcl-6 in paraffin-embedded tissue sections from 32 patients who had surgically resected primary intestinal lymphomas. We then correlated the expression of CD10 protein with various clinical parameters. Results. - Fifteen of 32 cases (47%) were CD10+, and CD10 positivity was correlated with intense Bcl-6 positivity. There were no significant differences in age, sex, serum lactate dehydrogenase level, and performance status between the CD10+ and CD10- groups. Patients with CD10+ lymphoma more frequently presented with stage I2 disease compared with those with CD10- lymphoma (P = .03). The response to treatment was significantly better in the CD10+ group than in the CD10- group (P = .02). An analysis of survival rates showed a trend for a longer overall survival duration in the CD10+ group compared with the CD10- group, although this was not statistically significant (P = .05). Conclusions. - We propose that more than half of primary intestinal large B-cell lymphomas have a germinal center cell origin. We also suggest that CD10 expression may be a prognostic indicator in patients with primary intestinal large B-cell lymphomas.
|Number of pages||5|
|Journal||Archives of Pathology and Laboratory Medicine|
|State||Published - Aug 2002|