TY - JOUR
T1 - CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells
AU - Amé-Thomas, Patricia
AU - Hoeller, Sylvia
AU - Artchounin, Catherine
AU - Misiak, Jan
AU - Braza, Mounia Sabrina
AU - Jean, Rachel
AU - Le Priol, Jérôme
AU - Monvoisin, Céline
AU - Martin, Nadine
AU - Gaulard, Philippe
AU - Tarte, Karin
N1 - Publisher Copyright:
© 2015 by The American Society of Hematology.
PY - 2015/4/9
Y1 - 2015/4/9
N2 - In follicular lymphoma (FL), follicular helper T cells (TFH) have been depicted as one of the main components of the malignant B-cell niche and a promising therapeutic target. Although defined by their capacity to sustain FL B-cell growth together with specific gene expression and cytokine secretion profiles, FL-TFH constitute a heterogeneous cell population. However, specific markers reflecting such functional heterogeneity are still lacking. In this study, we demonstrate that CD10 identifies a subset of fully functional germinal center TFH in normal secondary lymphoid organs. Importantly, this subset is amplified in the FL context, unlike in other B-cell lymphomas with a follicular growth pattern. Furthermore, whereas FL-TFH produce high levels of interleukin (IL)-21 and low levels of IL-17 irrespectively of their CD10 expression, CD10pos FL-TFH specifically exhibit an IL-4hiIFN-γloTNF-αhi cytokine profile associated with a high capacity to sustain directly and indirectly malignant B-cell survival. Altogether, our results highlight the important role of this novel functional subset in the FL cell niche.
AB - In follicular lymphoma (FL), follicular helper T cells (TFH) have been depicted as one of the main components of the malignant B-cell niche and a promising therapeutic target. Although defined by their capacity to sustain FL B-cell growth together with specific gene expression and cytokine secretion profiles, FL-TFH constitute a heterogeneous cell population. However, specific markers reflecting such functional heterogeneity are still lacking. In this study, we demonstrate that CD10 identifies a subset of fully functional germinal center TFH in normal secondary lymphoid organs. Importantly, this subset is amplified in the FL context, unlike in other B-cell lymphomas with a follicular growth pattern. Furthermore, whereas FL-TFH produce high levels of interleukin (IL)-21 and low levels of IL-17 irrespectively of their CD10 expression, CD10pos FL-TFH specifically exhibit an IL-4hiIFN-γloTNF-αhi cytokine profile associated with a high capacity to sustain directly and indirectly malignant B-cell survival. Altogether, our results highlight the important role of this novel functional subset in the FL cell niche.
UR - http://www.scopus.com/inward/record.url?scp=84927549503&partnerID=8YFLogxK
U2 - 10.1182/blood-2015-02-625152
DO - 10.1182/blood-2015-02-625152
M3 - Article
C2 - 25733581
AN - SCOPUS:84927549503
SN - 0006-4971
VL - 125
SP - 2381
EP - 2385
JO - Blood
JF - Blood
IS - 15
ER -