CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue

Donald N. Cook; Dina M. Prosser; Reinhold Forster; Jiwen Zhang; Nelly A. Kuklin; Susan J. Abbondanzo; Xiao Da Niu; Shu Cheng Chen; Denise J. Manfra; Maria T. Wiekowski; Lee M. Sullivan; Sidney R. Smith; Harry B. Greenberg; Satwant K. Narula; Martin Lipp; Sergio A. Lira

doi:10.1016/S1074-7613(00)80201-0

CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue

Donald N. Cook
, Dina M. Prosser
, Reinhold Forster
, Jiwen Zhang
, Nelly A. Kuklin
, Susan J. Abbondanzo
, Xiao Da Niu
, Shu Cheng Chen
, Denise J. Manfra
, Maria T. Wiekowski
, Lee M. Sullivan
, Sidney R. Smith
, Harry B. Greenberg
, Satwant K. Narula
, Martin Lipp
, Sergio A. Lira

Research output: Contribution to journal › Article › peer-review

445 Scopus citations

Abstract

Chemokine-directed migration of leukocyte subsets may contribute to the qualitative differences between systemic and mucosal immunity. Here, we demonstrate that in mice lacking the chemokine receptor CCR6, dendritic cells expressing CD11c and CD11b are absent from the subepithelial dome of Peyer's patches. These mice also have an impaired humoral immune response to orally administered antigen and to the enteropathic virus rotavirus. In addition, CCR6(-/-) mice have a 2-fold to 15-fold increase in cells of select T lymphocyte populations within the mucosa, including CD4⁺ and CD8⁺ αβ-TCR T cells. By contrast, systemic immune responses to subcutaneous antigens in CCR6(-/-) mice are normal. These findings demonstrate that CCR6 is a mucosa-specific regulator of humoral immunity and lymphocyte homeostasis in the intestinal mucosa.

Original language	English
Pages (from-to)	495-503
Number of pages	9
Journal	Immunity
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/S1074-7613(00)80201-0
State	Published - 2000
Externally published	Yes

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Cook, D. N., Prosser, D. M., Forster, R., Zhang, J., Kuklin, N. A., Abbondanzo, S. J., Niu, X. D., Chen, S. C., Manfra, D. J., Wiekowski, M. T., Sullivan, L. M., Smith, S. R., Greenberg, H. B., Narula, S. K., Lipp, M., & Lira, S. A. (2000). CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity, 12(5), 495-503. https://doi.org/10.1016/S1074-7613(00)80201-0

@article{9a0b7fcd1b064edd800fa0281f263871,

title = "CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue",

abstract = "Chemokine-directed migration of leukocyte subsets may contribute to the qualitative differences between systemic and mucosal immunity. Here, we demonstrate that in mice lacking the chemokine receptor CCR6, dendritic cells expressing CD11c and CD11b are absent from the subepithelial dome of Peyer's patches. These mice also have an impaired humoral immune response to orally administered antigen and to the enteropathic virus rotavirus. In addition, CCR6(-/-) mice have a 2-fold to 15-fold increase in cells of select T lymphocyte populations within the mucosa, including CD4+ and CD8+ αβ-TCR T cells. By contrast, systemic immune responses to subcutaneous antigens in CCR6(-/-) mice are normal. These findings demonstrate that CCR6 is a mucosa-specific regulator of humoral immunity and lymphocyte homeostasis in the intestinal mucosa.",

author = "Cook, \{Donald N.\} and Prosser, \{Dina M.\} and Reinhold Forster and Jiwen Zhang and Kuklin, \{Nelly A.\} and Abbondanzo, \{Susan J.\} and Niu, \{Xiao Da\} and Chen, \{Shu Cheng\} and Manfra, \{Denise J.\} and Wiekowski, \{Maria T.\} and Sullivan, \{Lee M.\} and Smith, \{Sidney R.\} and Greenberg, \{Harry B.\} and Narula, \{Satwant K.\} and Martin Lipp and Lira, \{Sergio A.\}",

note = "Funding Information: The authors thank Petronio Zalamea, Linda Hamilton, Channa Young, Aparna Subramaniam, Lisa Tardelli, Yuetian Chen, Carol Terminelli, Georgetta Denhardt, Nancy Robertson, Margaret Monahan, Tong-Yuan Yang, and Michael Leach for scientific assistance. We also thank Oliver Smithies, U. of N. Carolina at Chapel Hill, for his gift of the plasmid pOSDupDel. H. B. G. and N. A. K. were supported by a Veteran's Administration merit review grant and National Institutes of Health grant AI 21632.",

year = "2000",

doi = "10.1016/S1074-7613(00)80201-0",

language = "English",

volume = "12",

pages = "495--503",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

number = "5",

}

Cook, DN, Prosser, DM, Forster, R, Zhang, J, Kuklin, NA, Abbondanzo, SJ, Niu, XD, Chen, SC, Manfra, DJ, Wiekowski, MT, Sullivan, LM, Smith, SR, Greenberg, HB, Narula, SK, Lipp, M & Lira, SA 2000, 'CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue', Immunity, vol. 12, no. 5, pp. 495-503. https://doi.org/10.1016/S1074-7613(00)80201-0

TY - JOUR

T1 - CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue

AU - Cook, Donald N.

AU - Prosser, Dina M.

AU - Forster, Reinhold

AU - Zhang, Jiwen

AU - Kuklin, Nelly A.

AU - Abbondanzo, Susan J.

AU - Niu, Xiao Da

AU - Chen, Shu Cheng

AU - Manfra, Denise J.

AU - Wiekowski, Maria T.

AU - Sullivan, Lee M.

AU - Smith, Sidney R.

AU - Greenberg, Harry B.

AU - Narula, Satwant K.

AU - Lipp, Martin

AU - Lira, Sergio A.

N1 - Funding Information: The authors thank Petronio Zalamea, Linda Hamilton, Channa Young, Aparna Subramaniam, Lisa Tardelli, Yuetian Chen, Carol Terminelli, Georgetta Denhardt, Nancy Robertson, Margaret Monahan, Tong-Yuan Yang, and Michael Leach for scientific assistance. We also thank Oliver Smithies, U. of N. Carolina at Chapel Hill, for his gift of the plasmid pOSDupDel. H. B. G. and N. A. K. were supported by a Veteran's Administration merit review grant and National Institutes of Health grant AI 21632.

PY - 2000

Y1 - 2000

N2 - Chemokine-directed migration of leukocyte subsets may contribute to the qualitative differences between systemic and mucosal immunity. Here, we demonstrate that in mice lacking the chemokine receptor CCR6, dendritic cells expressing CD11c and CD11b are absent from the subepithelial dome of Peyer's patches. These mice also have an impaired humoral immune response to orally administered antigen and to the enteropathic virus rotavirus. In addition, CCR6(-/-) mice have a 2-fold to 15-fold increase in cells of select T lymphocyte populations within the mucosa, including CD4+ and CD8+ αβ-TCR T cells. By contrast, systemic immune responses to subcutaneous antigens in CCR6(-/-) mice are normal. These findings demonstrate that CCR6 is a mucosa-specific regulator of humoral immunity and lymphocyte homeostasis in the intestinal mucosa.

AB - Chemokine-directed migration of leukocyte subsets may contribute to the qualitative differences between systemic and mucosal immunity. Here, we demonstrate that in mice lacking the chemokine receptor CCR6, dendritic cells expressing CD11c and CD11b are absent from the subepithelial dome of Peyer's patches. These mice also have an impaired humoral immune response to orally administered antigen and to the enteropathic virus rotavirus. In addition, CCR6(-/-) mice have a 2-fold to 15-fold increase in cells of select T lymphocyte populations within the mucosa, including CD4+ and CD8+ αβ-TCR T cells. By contrast, systemic immune responses to subcutaneous antigens in CCR6(-/-) mice are normal. These findings demonstrate that CCR6 is a mucosa-specific regulator of humoral immunity and lymphocyte homeostasis in the intestinal mucosa.

UR - https://www.scopus.com/pages/publications/0033679107

U2 - 10.1016/S1074-7613(00)80201-0

DO - 10.1016/S1074-7613(00)80201-0

M3 - Article

C2 - 10843382

AN - SCOPUS:0033679107

SN - 1074-7613

VL - 12

SP - 495

EP - 503

JO - Immunity

JF - Immunity

IS - 5

ER -

CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue

Abstract

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