Cathepsin K inhibitor-polymer conjugates: Potential drugs for the treatment of osteoporosis and rheumatoid arthritis

D. Wang; W. Li; M. Pechar; P. Kopečková; D. Brömme; J. Kopeček

doi:10.1016/j.ijpharm.2003.03.003

Cathepsin K inhibitor-polymer conjugates: Potential drugs for the treatment of osteoporosis and rheumatoid arthritis

D. Wang, W. Li, M. Pechar, P. Kopečková, D. Brömme, J. Kopeček

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery systems are addressed.

Original language	English
Pages (from-to)	73-79
Number of pages	7
Journal	International Journal of Pharmaceutics
Volume	277
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2003.03.003
State	Published - 11 Jun 2004

Keywords

Antiresorptive
Cathepsin K
Inhibitor-polymer conjugates
Resorption lacuna
Semitelechelic HPMA polymer
mPEG

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10.1016/j.ijpharm.2003.03.003

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@article{eeac37242ef14b78973816691a558026,

title = "Cathepsin K inhibitor-polymer conjugates: Potential drugs for the treatment of osteoporosis and rheumatoid arthritis",

abstract = "The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery systems are addressed.",

keywords = "Antiresorptive, Cathepsin K, Inhibitor-polymer conjugates, Resorption lacuna, Semitelechelic HPMA polymer, mPEG",

author = "D. Wang and W. Li and M. Pechar and P. Kope{\v c}kov{\'a} and D. Br{\"o}mme and J. Kope{\v c}ek",

note = "Funding Information: This research was supported in part by NIH Grant EB00251 (D.W., M.P., P.K., and J. K.) and by the NIH Grant AR46182 and the Biomedical Science Grant from the Arthritis Foundation (W.L. and D.B.).",

year = "2004",

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doi = "10.1016/j.ijpharm.2003.03.003",

language = "English",

volume = "277",

pages = "73--79",

journal = "International Journal of Pharmaceutics",

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TY - JOUR

T1 - Cathepsin K inhibitor-polymer conjugates

T2 - Potential drugs for the treatment of osteoporosis and rheumatoid arthritis

AU - Wang, D.

AU - Li, W.

AU - Pechar, M.

AU - Kopečková, P.

AU - Brömme, D.

AU - Kopeček, J.

N1 - Funding Information: This research was supported in part by NIH Grant EB00251 (D.W., M.P., P.K., and J. K.) and by the NIH Grant AR46182 and the Biomedical Science Grant from the Arthritis Foundation (W.L. and D.B.).

PY - 2004/6/11

Y1 - 2004/6/11

N2 - The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery systems are addressed.

AB - The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery systems are addressed.

KW - Antiresorptive

KW - Cathepsin K

KW - Inhibitor-polymer conjugates

KW - Resorption lacuna

KW - Semitelechelic HPMA polymer

KW - mPEG

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U2 - 10.1016/j.ijpharm.2003.03.003

DO - 10.1016/j.ijpharm.2003.03.003

M3 - Article

C2 - 15158970

AN - SCOPUS:2442690116

SN - 0378-5173

VL - 277

SP - 73

EP - 79

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Cathepsin K inhibitor-polymer conjugates: Potential drugs for the treatment of osteoporosis and rheumatoid arthritis

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Keywords

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