TY - JOUR
T1 - Catatonia and Autoimmune Conditions in Children and Adolescents
T2 - Should We Consider a Therapeutic Challenge?
AU - Ferrafiat, Vladimir
AU - Raffin, Marie
AU - Deiva, Kumaran
AU - Salle-Collemiche, Xavier
AU - Lepine, Anne
AU - Spodenkiewicz, Michel
AU - Michelet, Isabelle
AU - Haroche, Julien
AU - Amoura, Zahir
AU - Gerardin, Priscille
AU - Cohen, David
AU - Consoli, Angèle
N1 - Publisher Copyright:
© Copyright 2017, Mary Ann Liebert, Inc. 2017.
PY - 2017/3
Y1 - 2017/3
N2 - Objective: Catatonia as a result of autoimmune conditions offers new therapeutic opportunities for patients that child and adolescent psychiatrists should consider. However, the diagnosis is sometimes challenging when an autoimmune signature is not identified. Methods: In this study, we aim to summarize seven cases from a 20-year series of 84 youths with catatonia, including three cases that represented a diagnostic challenge because of the absence of positive autoimmune testing. Results: Immunosuppressive/modulatory treatment improved catatonic and psychotic features in all cases. Conclusion: To facilitate treatment decision-making, we propose a causality assessment score and a treatment algorithm, which may help clinicians consider whether an autoimmune condition is associated with catatonia.
AB - Objective: Catatonia as a result of autoimmune conditions offers new therapeutic opportunities for patients that child and adolescent psychiatrists should consider. However, the diagnosis is sometimes challenging when an autoimmune signature is not identified. Methods: In this study, we aim to summarize seven cases from a 20-year series of 84 youths with catatonia, including three cases that represented a diagnostic challenge because of the absence of positive autoimmune testing. Results: Immunosuppressive/modulatory treatment improved catatonic and psychotic features in all cases. Conclusion: To facilitate treatment decision-making, we propose a causality assessment score and a treatment algorithm, which may help clinicians consider whether an autoimmune condition is associated with catatonia.
KW - Acute psychotic episode
KW - Autoimmune condition
KW - Catatonia
KW - Immunosuppressive treatment
KW - Treatment algorithm
UR - https://www.scopus.com/pages/publications/85016131146
U2 - 10.1089/cap.2015.0086
DO - 10.1089/cap.2015.0086
M3 - Article
C2 - 27093093
AN - SCOPUS:85016131146
SN - 1044-5463
VL - 27
SP - 167
EP - 176
JO - Journal of Child and Adolescent Psychopharmacology
JF - Journal of Child and Adolescent Psychopharmacology
IS - 2
ER -