Ca2+ sparks in heart muscle

W. Jonathan Lederer; Silvia Guatimosim; Long Sheng Song; Eric A. Sobie; Hali Hartmann; Valeriy Lukyanenko

Ca²⁺ sparks in heart muscle

W. Jonathan Lederer, Silvia Guatimosim, Long Sheng Song, Eric A. Sobie, Hali Hartmann, Valeriy Lukyanenko

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The spatial organization of the cardiac myocyte is critical to its function. Cardiac Ca²⁺ signaling depends on interplay between membrane currents, local concentration changes of diverse ions and the specialized structures. The Ca²⁺ spark, the elementary unit of excitation-contraction coupling in heart, is thus a product of both global and local processes. Our understanding of both normal and pathological cellular behavior in heart is enhanced by studying Ca²⁺ sparks.

Original language	English
Pages (from-to)	602-603
Number of pages	2
Journal	Journal of Muscle Research and Cell Motility
Volume	25
Issue number	8
State	Published - 2004
Externally published	Yes

Cite this

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title = "Ca2+ sparks in heart muscle",

abstract = "The spatial organization of the cardiac myocyte is critical to its function. Cardiac Ca2+ signaling depends on interplay between membrane currents, local concentration changes of diverse ions and the specialized structures. The Ca2+ spark, the elementary unit of excitation-contraction coupling in heart, is thus a product of both global and local processes. Our understanding of both normal and pathological cellular behavior in heart is enhanced by studying Ca2+ sparks.",

author = "Lederer, {W. Jonathan} and Silvia Guatimosim and Song, {Long Sheng} and Sobie, {Eric A.} and Hali Hartmann and Valeriy Lukyanenko",

year = "2004",

language = "English",

volume = "25",

pages = "602--603",

journal = "Journal of Muscle Research and Cell Motility",

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T1 - Ca2+ sparks in heart muscle

AU - Lederer, W. Jonathan

AU - Guatimosim, Silvia

AU - Song, Long Sheng

AU - Sobie, Eric A.

AU - Hartmann, Hali

AU - Lukyanenko, Valeriy

PY - 2004

Y1 - 2004

N2 - The spatial organization of the cardiac myocyte is critical to its function. Cardiac Ca2+ signaling depends on interplay between membrane currents, local concentration changes of diverse ions and the specialized structures. The Ca2+ spark, the elementary unit of excitation-contraction coupling in heart, is thus a product of both global and local processes. Our understanding of both normal and pathological cellular behavior in heart is enhanced by studying Ca2+ sparks.

AB - The spatial organization of the cardiac myocyte is critical to its function. Cardiac Ca2+ signaling depends on interplay between membrane currents, local concentration changes of diverse ions and the specialized structures. The Ca2+ spark, the elementary unit of excitation-contraction coupling in heart, is thus a product of both global and local processes. Our understanding of both normal and pathological cellular behavior in heart is enhanced by studying Ca2+ sparks.

UR - http://www.scopus.com/inward/record.url?scp=17644380614&partnerID=8YFLogxK

M3 - Article

C2 - 16118853

AN - SCOPUS:17644380614

SN - 0142-4319

VL - 25

SP - 602

EP - 603

JO - Journal of Muscle Research and Cell Motility

JF - Journal of Muscle Research and Cell Motility

IS - 8

ER -

Ca2+ sparks in heart muscle

Abstract

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Ca²⁺ sparks in heart muscle