Case report: Reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication

S. Krahenbuhl; B. Sauter; H. Kupferschmidt; M. Krause; P. A. Wyss; P. J. Meier

doi:10.1097/00000441-199506000-00003

Case report: Reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication

S. Krahenbuhl, B. Sauter, H. Kupferschmidt, M. Krause, P. A. Wyss, P. J. Meier

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Pimozide is a diphenylpiperidine neuroleptic with well characterized cardiovascular side effects including QT prolongation. So far, life- threatening cardiac arrhythmias, in particular torsades de pointes, have not been described in patients treated with pimozide. The authors describe a patient in whom torsades de pointes developed after the ingestion of 800 mg pimozide as a suicide attempt. After intravenous treatment with lidocaine and magnesium, the patient recovered completely and the QT interval had normalized 5 days after the intoxication. Potential mechanisms leading to torsades de pointes in patients treated with pimozide are discussed.

Original language	English
Pages (from-to)	315-316
Number of pages	2
Journal	American Journal of the Medical Sciences
Volume	309
Issue number	6
DOIs	https://doi.org/10.1097/00000441-199506000-00003
State	Published - 1995
Externally published	Yes

Keywords

Intoxication
Neuroleptics
QT prolongation
Side effects
Torsades de pointes

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10.1097/00000441-199506000-00003

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abstract = "Pimozide is a diphenylpiperidine neuroleptic with well characterized cardiovascular side effects including QT prolongation. So far, life- threatening cardiac arrhythmias, in particular torsades de pointes, have not been described in patients treated with pimozide. The authors describe a patient in whom torsades de pointes developed after the ingestion of 800 mg pimozide as a suicide attempt. After intravenous treatment with lidocaine and magnesium, the patient recovered completely and the QT interval had normalized 5 days after the intoxication. Potential mechanisms leading to torsades de pointes in patients treated with pimozide are discussed.",

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AU - Sauter, B.

AU - Kupferschmidt, H.

AU - Krause, M.

AU - Wyss, P. A.

AU - Meier, P. J.

PY - 1995

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AB - Pimozide is a diphenylpiperidine neuroleptic with well characterized cardiovascular side effects including QT prolongation. So far, life- threatening cardiac arrhythmias, in particular torsades de pointes, have not been described in patients treated with pimozide. The authors describe a patient in whom torsades de pointes developed after the ingestion of 800 mg pimozide as a suicide attempt. After intravenous treatment with lidocaine and magnesium, the patient recovered completely and the QT interval had normalized 5 days after the intoxication. Potential mechanisms leading to torsades de pointes in patients treated with pimozide are discussed.

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Case report: Reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication

Abstract

Keywords

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