Case report: A great mimicker of neoplasm: Pulmonary cryptococcosis in an immunocompetent host after high-altitude descent

Keely Johnson, Umaima Dhamrah, Aisha Amin, Joseph Masci

Research output: Contribution to journalArticlepeer-review

Abstract

Cryptococcus exposure in certain global regions is common and yet virulence in the immunocompetent host remains rare. Radiological findings of pulmonary cryptococcosis may include nonspecific lung nodules or masses indistinguishable from lung cancer or pulmonary tuberculosis. We present a case of an immunocompetent diabetic female who presented with progressively worsening pleuritic chest pain and cough with travel between Tibet and New York 2 months earlier. Chest imaging demonstrated a large lobulated mass, acid-fast bacillus smears were negative, and our patient underwent pulmonary biopsy, which grew rare budding yeast later confirmed by mucicarmine staining as Cryptococcus. Our patient was successfully treated with fluconazole therapy. We hypothesize that the high altitude of Tibet may allow for clinical latency followed by symptomatic reactivation on descent. A raised index of suspicion for pulmonary cryptococcosis with careful attention to travel history is expected to facilitate timely diagnosis.

Original languageEnglish
Pages (from-to)454-457
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume105
Issue number2
DOIs
StatePublished - Aug 2021
Externally publishedYes

Fingerprint

Dive into the research topics of 'Case report: A great mimicker of neoplasm: Pulmonary cryptococcosis in an immunocompetent host after high-altitude descent'. Together they form a unique fingerprint.

Cite this