Case-Fatality Ratio of Blood Culture-Confirmed Typhoid Fever in Dhaka, Bangladesh

Alexander T. Yu, Nuhu Amin, Muhammad Waliur Rahman, Emily S. Gurley, Kazi Mizanur Rahman, Stephen P. Luby

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

With impending rollout of new conjugate typhoid vaccines, better estimates of typhoid case-fatality ratio are needed for countries to set priorities for public health programs. We enrolled 1425 patients of all ages with blood culture-confirmed Salmonella Typhi from laboratory networks serving inpatients and outpatients in Dhaka, Bangladesh. Participants were asked about symptoms and complications including death experienced over a median 3-month period following blood culture diagnosis. Four fatal cases were identified (case-fatality ratio of 0.3% [95% confidence interval,.05%-.55%]). Applying this case-fatality ratio to global typhoid burden estimates would reduce deaths by 70%.

Original languageEnglish
Pages (from-to)S222-S226
JournalJournal of Infectious Diseases
Volume218
DOIs
StatePublished - 10 Nov 2018
Externally publishedYes

Keywords

  • case-fatality ratio
  • enteric fever
  • global burden of disease
  • laboratory-based surveillance
  • typhoid

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