TY - JOUR
T1 - Cardiovascular pathophysiology in chronic kidney disease
T2 - Opportunities to transition from disease to health
AU - Tomey, Matthew I.
AU - Winston, Jonathan A.
PY - 2014
Y1 - 2014
N2 - Background: Chronic kidney disease (CKD) is common, and is associated with a high burden of cardiovascular disease. This cardiovascular risk is incompletely explained by traditional risk factors, calling attention to a need to better understand the pathways in CKD contributing to adverse cardiovascular outcomes. Findings: Pathophysiological derangements associated with CKD, including disordered sodium, potassium, and water homeostasis, renin-angiotensin-aldosterone and sympathetic activity, anemia, bone and mineral metabolism, uremia, and toxin accumulation may contribute directly to progression of cardiovascular disease and adverse outcomes. Conclusion: Improving cardiovascular health in patients with CKD requires improved understanding of renocardiac pathophysiology. Ultimately, the most successful strategy may be prevention of incident CKD itself.
AB - Background: Chronic kidney disease (CKD) is common, and is associated with a high burden of cardiovascular disease. This cardiovascular risk is incompletely explained by traditional risk factors, calling attention to a need to better understand the pathways in CKD contributing to adverse cardiovascular outcomes. Findings: Pathophysiological derangements associated with CKD, including disordered sodium, potassium, and water homeostasis, renin-angiotensin-aldosterone and sympathetic activity, anemia, bone and mineral metabolism, uremia, and toxin accumulation may contribute directly to progression of cardiovascular disease and adverse outcomes. Conclusion: Improving cardiovascular health in patients with CKD requires improved understanding of renocardiac pathophysiology. Ultimately, the most successful strategy may be prevention of incident CKD itself.
KW - Cardiorenal syndrome
KW - Cardiovascular disease
KW - Chronic kidney disease
KW - Renocardiac syndrome
UR - http://www.scopus.com/inward/record.url?scp=84904512246&partnerID=8YFLogxK
U2 - 10.1016/j.aogh.2013.12.007
DO - 10.1016/j.aogh.2013.12.007
M3 - Review article
C2 - 24751567
AN - SCOPUS:84904512246
VL - 80
SP - 69
EP - 76
JO - Annals of Global Health
JF - Annals of Global Health
SN - 0027-2507
IS - 1
ER -