Cardiovascular pathophysiology in chronic kidney disease: Opportunities to transition from disease to health

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Abstract

Background: Chronic kidney disease (CKD) is common, and is associated with a high burden of cardiovascular disease. This cardiovascular risk is incompletely explained by traditional risk factors, calling attention to a need to better understand the pathways in CKD contributing to adverse cardiovascular outcomes. Findings: Pathophysiological derangements associated with CKD, including disordered sodium, potassium, and water homeostasis, renin-angiotensin-aldosterone and sympathetic activity, anemia, bone and mineral metabolism, uremia, and toxin accumulation may contribute directly to progression of cardiovascular disease and adverse outcomes. Conclusion: Improving cardiovascular health in patients with CKD requires improved understanding of renocardiac pathophysiology. Ultimately, the most successful strategy may be prevention of incident CKD itself.

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalAnnals of Global Health
Volume80
Issue number1
DOIs
StatePublished - 2014

Keywords

  • Cardiorenal syndrome
  • Cardiovascular disease
  • Chronic kidney disease
  • Renocardiac syndrome

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