Cardiovascular effects of a nifedipine infusion during fentanyl-nitrous oxide anesthesia in dogs

Richard M. Griffin, Ivan Dimich, Roy Jurado, Vasilios Pratilas, Howard Shiang, Richard Fagerstrom, Joel A. Kaplan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The hemodynamic effects of a nifedipine infusion were investigated in eight dogs given fentanyl/ pancuronium/nitrous oxide/oxygen anesthesia. Nifedipine (20 μg/kg) was given intravenously over two minutes immediately prior to each 30-minute infusion at 2 μg/kg/min, 4 μg/kg/min, and 6 μg/ kg/min. The range of plasma nifedipine levels obtained was 52.1 to 113.7 ng/mL. The predominant hemodynamic effects were significant reductions systemic vascular resistance (SVR) and mean aortic pressure (MAP), accompanied by a rise in cardiac index and heart rate (HR). Administration of calcium chloride (20 mg/kg) after the nifedipine infusion had no effect on SVR or MAP, but HR was significantly reduced. Serum epinephrine and norepinephrine levels increased after the infusion of nifedipine and suggested that fentanyl did not completely overcome the sympathetic response to the profound vasodilatation. The resulting tachycardia in combination with diastolic hypotension from nifedipine could have a detrimental effect on the myocardial oxygen balance.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalJournal of Cardiothoracic Anesthesia
Volume3
Issue number1
DOIs
StatePublished - Feb 1989
Externally publishedYes

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